van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal AC (2010) RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res 38, 1922-31 20026589

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K394-sm - HIF2A (human) ▲

Modsite: NFLFTkLkEEPEELA SwissProt Entrez-Gene Orthologous residues HIF2A (human): K394‑sm, HIF2A (mouse): K394‑sm, HIF2A (rat): K394‑sm Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes DESUMOYLASE SENP1 (human) transfection of wild-type enzyme, siRNA inhibition of enzyme Downstream Regulation Effect of modification (process):  transcription, inhibited