Curated Information
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Home > Curated Information Page > PubMed Id: 17525340
Wang B, et al. (2007) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 316, 1194-8 17525340
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S404-p - Abraxas (human)
Modsite: MkGFGEYsRsPtF__ SwissProt Entrez-Gene
Orthologous residues
Abraxas (human): S404‑p, Abraxas (mouse): P402‑p, Abraxas (rat): P400‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase

S406-p - Abraxas (human)
Modsite: GFGEYsRsPtF____ SwissProt Entrez-Gene
Orthologous residues
Abraxas (human): S406‑p, Abraxas (mouse): S404‑p, Abraxas (rat): S402‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  DNA repair, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BRCA1 (human) BRCT Induces molecular association, regulation pull-down assay
Comments:  Abraxas and RAP80 form a complex that interacts with BRCA1.

S140-p - RAP80 (human)
Modsite: PLAtGPssQsHQEkt SwissProt Entrez-Gene
Orthologous residues
RAP80 (human): S140‑p, RAP80 iso3 (human): S62‑p, RAP80 (mouse): S140‑p, RAP80 (rat): S140‑p

S402-p - RAP80 (human)
Modsite: ttSHGQSsQGIVEET SwissProt Entrez-Gene
Orthologous residues
RAP80 (human): S402‑p, RAP80 iso3 (human): S324‑p, RAP80 (mouse): S402‑p, RAP80 (rat): S402‑p

S419-p - RAP80 (human)
Modsite: EGNsVPAsQsVAALT SwissProt Entrez-Gene
Orthologous residues
RAP80 (human): S419‑p, RAP80 iso3 (human): S341‑p, RAP80 (mouse): T427‑p, RAP80 (rat): S427‑p