Curated Information
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Home > Curated Information Page > PubMed Id: 16928683
Knowles PP, et al. (2006) Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem 281, 33577-87 16928683
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y752-p - Ret (human)
Modsite: HLKGRAGyTtVAVKM SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y752‑p, Ret iso2 (human): Y752‑p, Ret iso3 (human): Y276‑p, Ret (mouse): Y753‑p, Ret iso2 (mouse): Y753‑p, Ret iso4 (mouse): Y702‑p, Ret (rat): Y753‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)

Y826-p - Ret (human)
Modsite: SRKVGPGyLGSGGSR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y826‑p, Ret iso2 (human): Y826‑p, Ret iso3 (human): Y350‑p, Ret (mouse): Y827‑p, Ret iso2 (mouse): Y827‑p, Ret iso4 (mouse): Y776‑p, Ret (rat): Y827‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)

Y900-p - Ret (human)
Modsite: FGLSRDVyEEDsyVK SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y900‑p, Ret iso2 (human): Y900‑p, Ret iso3 (human): Y424‑p, Ret (mouse): Y901‑p, Ret iso2 (mouse): Y901‑p, Ret iso4 (mouse): , Ret (rat): Y901‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y905-p - Ret (human)
Modsite: DVyEEDsyVKRsQGR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y905‑p, Ret iso2 (human): Y905‑p, Ret iso3 (human): Y429‑p, Ret (mouse): Y906‑p, Ret iso2 (mouse): Y906‑p, Ret iso4 (mouse): , Ret (rat): Y906‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y928-p - Ret (human)
Modsite: ESLFDHIyTTQSDVW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y928‑p, Ret iso2 (human): Y928‑p, Ret iso3 (human): Y452‑p, Ret (mouse): Y929‑p, Ret iso2 (mouse): Y929‑p, Ret iso4 (mouse): , Ret (rat): Y929‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)

Y981-p - Ret (human)
Modsite: DNCSEEMyRLMLQCW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y981‑p, Ret iso2 (human): Y981‑p, Ret iso3 (human): Y505‑p, Ret (mouse): Y982‑p, Ret iso2 (mouse): Y982‑p, Ret iso4 (mouse): , Ret (rat): Y982‑p
Characterization
Methods used to characterize site in vivo mass spectrometry (in vitro)