Curated Information
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Home > Curated Information Page > PubMed Id: 11283256
Tan I, Seow KT, Lim L, Leung T (2001) Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Mol Cell Biol 21, 2767-78 11283256
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S222-p - MRCKA (human)
Modsite: IRLADFGsCLKLMED SwissProt Entrez-Gene
Orthologous residues
MRCKA (human): S222‑p, MRCKA iso2 (human): S222‑p, MRCKA iso3 (human): S222‑p, MRCKA iso6 (human): S222‑p, MRCKA (mouse): S222‑p, MRCKA (rat): S222‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey

S234-p - MRCKA (human)
Modsite: MEDGTVQsSVAVGtP SwissProt Entrez-Gene
Orthologous residues
MRCKA (human): S234‑p, MRCKA iso2 (human): S234‑p, MRCKA iso3 (human): S234‑p, MRCKA iso6 (human): S234‑p, MRCKA (mouse): S234‑p, MRCKA (rat): S234‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MRCKA (human)
Comments:  autophosphorylation
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cytoskeletal reorganization

T240-p - MRCKA (human)
Modsite: QsSVAVGtPDYISPE SwissProt Entrez-Gene
Orthologous residues
MRCKA (human): T240‑p, MRCKA iso2 (human): T240‑p, MRCKA iso3 (human): T240‑p, MRCKA iso6 (human): T240‑p, MRCKA (mouse): T240‑p, MRCKA (rat): T240‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MRCKA (human)
Comments:  autophosphorylation
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cytoskeletal reorganization

T403-p - MRCKA (human)
Modsite: HLPFVGFtYTSSCVL SwissProt Entrez-Gene
Orthologous residues
MRCKA (human): T403‑p, MRCKA iso2 (human): T403‑p, MRCKA iso3 (human): T403‑p, MRCKA iso6 (human): T403‑p, MRCKA (mouse): T403‑p, MRCKA (rat): T403‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Species studied:  green monkey
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MRCKA (human)
Comments:  autophosphorylation
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  cytoskeletal reorganization