Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 11350745
Benes C, Soltoff SP (2001) Modulation of PKCdelta tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases. Am J Physiol Cell Physiol 280, C1498-510 11350745
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

T505-p - PKCD (rat)
Modsite: FGENRAstFCGTPDy SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  parotid acinar-salivary gland
Cellular systems studied:  primary cultured cells
Species studied:  rat
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTP1B (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester no change compared to control
LY294002, phorbol_ester no change compared to control
phorbol_ester, rapamycin no change compared to control
LY294002 no change compared to control
rapamycin no change compared to control
wortmannin no change compared to control
carbachol no change compared to control
carbachol no change compared to control
carbachol no change compared to control

S662-p - PKCD (rat)
Modsite: QtAFKGFsFVNPKYE SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S664‑p, PKCD iso2 (human): S695‑p, PKCD (mouse): S662‑p, PKCD iso2 (mouse): S688‑p, PKCD (rat): S662‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  parotid acinar-salivary gland
Cellular systems studied:  primary cultured cells
Species studied:  rat
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTP1B (human)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
carbachol no change compared to control
carbachol no change compared to control
carbachol no change compared to control
phorbol_ester no change compared to control
phorbol_ester, rapamycin no change compared to control
LY294002, phorbol_ester no change compared to control
wortmannin no change compared to control
rapamycin no change compared to control
LY294002 no change compared to control