Curated Information
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Home > Curated Information Page > PubMed Id: 8042986
Cazaubon S, Bornancin F, Parker PJ (1994) Threonine-497 is a critical site for permissive activation of protein kinase C alpha. Biochem J 301 ( Pt 2), 443-8 8042986
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T494-p - PKCA (cow)
Modsite: EHMMDGVttRtFCGT SwissProt Entrez-Gene
Orthologous residues
PKCA (human): T494‑p, PKCA (mouse): T494‑p, PKCA (rat): T494‑p, PKCA (cow): T494‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines

T495-p - PKCA (cow)
Modsite: HMMDGVttRtFCGTP SwissProt Entrez-Gene
Orthologous residues
PKCA (human): T495‑p, PKCA (mouse): T495‑p, PKCA (rat): T495‑p, PKCA (cow): T495‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines

T497-p - PKCA (cow)
Modsite: MDGVttRtFCGTPDY SwissProt Entrez-Gene
Orthologous residues
PKCA (human): T497‑p, PKCA (mouse): T497‑p, PKCA (rat): T497‑p, PKCA (cow): T497‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  COS (fibroblast)
Cellular systems studied:  cell lines
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester increase
Ca(2+) increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced