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Home > Curated Information Page > PubMed Id: 7935391
Arvidsson AK, et al. (1994) Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Mol Cell Biol 14, 6715-26 7935391
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y716-p - PDGFRB (human)
Modsite: RPPsAELysNALPVG SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y716‑p, PDGFRB (mouse): Y715‑p, PDGFRB (rat): Y715‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GRB2 (human) SH2 Induces pull-down assay, co-immunoprecipitation
Comments:  Ras activation

Y740-p - PDGFRB (human)
Modsite: TGESDGGyMDMSKDE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell cycle regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces co-immunoprecipitation

Y751-p - PDGFRB (human)
Modsite: SKDESVDyVPMLDMK SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell cycle regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces co-immunoprecipitation

Y771-p - PDGFRB (human)
Modsite: ADIESSNyMAPyDNy SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y771‑p, PDGFRB (mouse): Y770‑p, PDGFRB (rat): Y770‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RASA1 (human) Induces co-immunoprecipitation

Y1009-p - PDGFRB (human)
Modsite: LDTSSVLyTAVQPNE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y1009‑p, PDGFRB (mouse): Y1008‑p, PDGFRB (rat): Y1008‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces co-immunoprecipitation