Curated Information
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Home > Curated Information Page > PubMed Id: 18048416
El-Shemerly M, et al. (2008) ATR-dependent pathways control hEXO1 stability in response to stalled forks. Nucleic Acids Res 36, 511-9 18048416
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S376-p - EXO1 (human)
Modsite: SIWHRNysPRPESGT SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S376‑p, EXO1 (mouse): C375‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S422-p - EXO1 (human)
Modsite: sIVKRPRsAELSEDD SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S422‑p, EXO1 (mouse): N421‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S454-p - EXO1 (human)
Modsite: SEGNKSLsFSEVFVP SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S454‑p, EXO1 (mouse): N452‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hydroxyurea increase
Downstream Regulation
Effect of modification (function):  protein degradation

T581-p - EXO1 (human)
Modsite: PDKATVFtDEESYSF SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): T581‑p, EXO1 (mouse): P572‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S598-p - EXO1 (human)
Modsite: SKFTRTIsPPTLGTL SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S598‑p, EXO1 (mouse): S589‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

T621-p - EXO1 (human)
Modsite: GLGDFSRtPsPSPST SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): T621‑p, EXO1 (mouse): T612‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hydroxyurea increase
Downstream Regulation
Effect of modification (function):  protein degradation

S623-p - EXO1 (human)
Modsite: GDFSRtPsPSPSTAL SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S623‑p, EXO1 (mouse): S614‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S639-p - EXO1 (human)
Modsite: QFRRKSDsPTSLPEN SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S639‑p, EXO1 (mouse): P630‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S660-p - EXO1 (human)
Modsite: QLKSEEssDDESHPL SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S660‑p, EXO1 (mouse): G653‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S674-p - EXO1 (human)
Modsite: LREEACSsQSQESGE SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S674‑p, EXO1 (mouse): S666‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human

S714-p - EXO1 (human)
Modsite: CNIKLLDsQSDQTSK SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S714‑p, EXO1 (mouse): N705‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hydroxyurea increase
MG132 hydroxyurea augment treatment-induced increase
ionizing_radiation no change compared to control
Downstream Regulation
Effect of modification (function):  protein degradation

S746-p - EXO1 (human)
Modsite: PGLYkSSsADsLStT SwissProt Entrez-Gene
Orthologous residues
EXO1 (human): S746‑p, EXO1 (mouse): S737‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human