Curated Information
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Home > Curated Information Page > PubMed Id: 30800215
Nozaki M, et al. (2019) LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer. Oncotarget 10, 1014-1030 30800215
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T1079-p - LATS1 (human)
Modsite: EHAFyEFtFRRFFDD SwissProt Entrez-Gene
Orthologous residues
LATS1 (human): T1079‑p, LATS1 (mouse): T1078‑p, LATS1 (rat): T1079‑p
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  signaling pathway regulation
Comments:  in SAS cell line; Hippo pathway

S408-p - LATS2 (human)
Modsite: PVPSRTNsFNSHQPR SwissProt Entrez-Gene
Orthologous residues
LATS2 (human): S408‑p, LATS2 (mouse): S386‑p, LATS2 (rat): S385‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Chk1 (human) increase
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  signaling pathway regulation
Comments:  in SAS cell line; Hippo pathway

S835-p - LATS2 (human)
Modsite: GSHVRQDsMEPSDLW SwissProt Entrez-Gene
Orthologous residues
LATS2 (human): S835‑p, LATS2 (mouse): S793‑p, LATS2 (rat): S793‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Chk1 (human) increase
Downstream Regulation
Effect of modification (function):  activity, induced, phosphorylation
Effect of modification (process):  signaling pathway regulation
Comments:  Chk1-dependent trans-autophosphorylation in SAS cell line, in SAS cell line; Hippo pathway

T1041-p - LATS2 (human)
Modsite: EHAFyEFtFRRFFDD SwissProt Entrez-Gene
Orthologous residues
LATS2 (human): T1041‑p, LATS2 (mouse): T999‑p, LATS2 (rat): T999‑p
Downstream Regulation
Effect of modification (function):  activity, induced
Effect of modification (process):  signaling pathway regulation
Comments:  in SAS cell line; Hippo pathway

T203-p - Snail1 (human)
Modsite: QGHVRtHtGEkPFSC SwissProt Entrez-Gene
Orthologous residues
Snail1 (human): T203‑p, Snail1 (mouse): T203‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LATS2 (human) increase
Downstream Regulation
Effect of modification (function):  activity, induced, intracellular localization, protein stabilization
Effect of modification (process):  carcinogenesis, induced, transcription, induced