Yang Y, et al. (2019) Connexin43 dephosphorylation at serine 282 is associated with connexin43-mediated cardiomyocyte apoptosis. Cell Death Differ 30770876

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S282-p - GJA1 (mouse) ▲

Modsite: tAPLsPMsPPGykLV SwissProt Entrez-Gene Orthologous residues GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  brain, fibroblast-heart, heart, liver, macrophage-bone marrow, myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  mouse, rat Downstream Regulation Effect of modification (process):  apoptosis, inhibited Comments:  cardiomyocyte homeostasis

S262-p - GJA1 (rat) ▲

Modsite: sPskDCGsPkyAyFN SwissProt Entrez-Gene Orthologous residues GJA1 (human): S262‑p, GJA1 (mouse): S262‑p, GJA1 (rat): S262‑p, GJA1 (rabbit): S262‑p, GJA1 (pig): S262‑p, GJA1 (hamster): S262‑p, GJA1 (cow): S263‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart, myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  mouse, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GJA1 (human) no change compared to control S279A and S282A mutations

S279-p - GJA1 (rat) ▲

Modsite: SSPTAPLsPMsPPGY SwissProt Entrez-Gene Orthologous residues GJA1 (human): S279‑p, GJA1 (mouse): S279‑p, GJA1 (rat): S279‑p, GJA1 (rabbit): S279‑p, GJA1 (pig): S279‑p, GJA1 (hamster): S279‑p, GJA1 (cow): S280‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  brain, fibroblast-heart, heart, liver, macrophage-bone marrow, myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  mouse, rat

S282-p - GJA1 (rat) ▲

Modsite: TAPLsPMsPPGYkLV SwissProt Entrez-Gene Orthologous residues GJA1 (human): S282‑p, GJA1 (mouse): S282‑p, GJA1 (rat): S282‑p, GJA1 (rabbit): S282‑p, GJA1 (pig): S282‑p, GJA1 (hamster): S282‑p, GJA1 (cow): S283‑p Characterization Methods used to characterize site in vivo:  immunoassay, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  brain, fibroblast-heart, heart, liver, macrophage-bone marrow, myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  mouse, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CBX no change compared to control 2-APB decrease Downstream Regulation Effect of modification (process):  apoptosis, inhibited Comments:  cardiomyocyte homeostasis

S368-p - GJA1 (rat) ▲

Modsite: QRPssRAssRAssRP SwissProt Entrez-Gene Orthologous residues GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart, myocyte-heart Cellular systems studied:  primary cultured cells Species studied:  mouse, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GJA1 (human) no change compared to control S279A and S282A mutations