Kohutova J, et al. (2018) Anti-arrhythmic Cardiac Phenotype Elicited by Chronic Intermittent Hypoxia Is Associated With Alterations in Connexin-43 Expression, Phosphorylation, and Distribution. Front Endocrinol (Lausanne) 9, 789 30740090

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S364-p - GJA1 (rat) ▲

Modsite: AIVDQRPsSRASSRA SwissProt Entrez-Gene Orthologous residues GJA1 (human): S364‑p, GJA1 (mouse): S364‑p, GJA1 (rat): S364‑p, GJA1 (rabbit): S364‑p, GJA1 (pig): S364‑p, GJA1 (hamster): S364‑p, GJA1 (cow): S365‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes hypoxia increase Intermittent hypobaric hypoxia Associated Diseases Diseases Alterations Comments ventricular tachycardia decreased

S365-p - GJA1 (rat) ▲

Modsite: IVDQRPSsRASSRAS SwissProt Entrez-Gene Orthologous residues GJA1 (human): S365‑p, GJA1 (mouse): S365‑p, GJA1 (rat): S365‑p, GJA1 (rabbit): S365‑p, GJA1 (pig): S365‑p, GJA1 (hamster): S365‑p, GJA1 (cow): S366‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes hypoxia increase Intermittent hypobaric hypoxia Associated Diseases Diseases Alterations Comments ventricular tachycardia decreased

S368-p - GJA1 (rat) ▲

Modsite: QRPSSRAsSRASSRP SwissProt Entrez-Gene Orthologous residues GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p Characterization Methods used to characterize site in vivo:  immunoassay, mass spectrometry, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  myocardium Cellular systems studied:  tissue Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes hypoxia increase Intermittent hypobaric hypoxia Downstream Regulation Effect of modification (function):  intracellular localization Associated Diseases Diseases Alterations Comments ventricular tachycardia decreased