Winer IS, Bommer GT, Gonik N, Fearon ER (2006) Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation. J Biol Chem 281, 26181-7 16849322

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K19-ub - CTNNB1 (human) ▲

Modsite: MAMEPDRkAAVsHWQ SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): K19‑ub, CTNNB1 (mouse): K19‑ub, CTNNB1 (rat): K19‑ub, CTNNB1 (rabbit): K19‑ub Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), RK3E (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes UBIQUITIN LIGASE BTRC (human) transfection of dominant-negative enzyme K19 is primary ubiquitination site. Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  carcinogenesis, inhibited, cell growth, inhibited, transcription, inhibited Comments:  when both sites are mutated induces TCF transcription and transformation; K19 is primary site of ubquitination

K49-ub - CTNNB1 (human) ▲

Modsite: TAPsLsGkGNPEEED SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): K49‑ub, CTNNB1 (mouse): K49‑ub, CTNNB1 (rat): K49‑ub, CTNNB1 (rabbit): K49‑ub Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial), RK3E (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes UBIQUITIN LIGASE BTRC (human) transfection of dominant-negative enzyme K19 is primary ubiquitination site. Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  carcinogenesis, inhibited, cell growth, inhibited, transcription, inhibited Comments:  when both sites are mutated induces TCF transcription and transformation; K19 is primary site of ubquitination