Curated Information
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Home > Curated Information Page > PubMed Id: 16849322
Winer IS, Bommer GT, Gonik N, Fearon ER (2006) Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation. J Biol Chem 281, 26181-7 16849322
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K19-ub - CTNNB1 (human)
Modsite: MAMEPDRkAAVsHWQ SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): K19‑ub, CTNNB1 (mouse): K19‑ub, CTNNB1 (rat): K19‑ub, CTNNB1 (rabbit): K19‑ub
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
UBIQUITIN LIGASE BTRC (human) transfection of dominant-negative enzyme K19 is primary ubiquitination site.
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  carcinogenesis, inhibited, cell growth, inhibited, transcription, inhibited
Comments:  when both sites are mutated induces TCF transcription and transformation; K19 is primary site of ubquitination

K49-ub - CTNNB1 (human)
Modsite: TAPsLsGkGNPEEED SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): K49‑ub, CTNNB1 (mouse): K49‑ub, CTNNB1 (rat): K49‑ub, CTNNB1 (rabbit): K49‑ub
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
UBIQUITIN LIGASE BTRC (human) transfection of dominant-negative enzyme K19 is primary ubiquitination site.
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  carcinogenesis, inhibited, cell growth, inhibited, transcription, inhibited
Comments:  when both sites are mutated induces TCF transcription and transformation; K19 is primary site of ubquitination