Chen F, et al. (2002) Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 99, 1990-5 11842186

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K151-ub - CDC25C (human) ▲

Modsite: MCsSsANkENDNGNL SwissProt Entrez-Gene Orthologous residues CDC25C (human): K151‑ub, CDC25C iso3 (human): K108‑ub, CDC25C (mouse): K150‑ub, CDC25C (frog): K154‑ub Characterization Methods used to characterize site in vivo:  immunoprecipitation, modification-specific antibody, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  BEAS-2B (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes arsenite, lactacystin increase Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  cell cycle regulation, cell growth, inhibited