Curated Information
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Home > Curated Information Page > PubMed Id: 19996295
Kim SS, et al. (2009) Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1. Cancer Res 69, 9291-300 19996295
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1152-p - BRCA1 (mouse)
Modsite: LRRESsRsPsPVTHA SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1189‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S1189‑p, BRCA1 (mouse): S1152‑p, BRCA1 (rat): S1153‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  mammary gland, skin
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  Brca1 S1152A/S1152A mutant mice
Downstream Regulation
Effect of modification (process):  apoptosis, altered
Comments:  required for proper skin structure and hair regeneration; confers resistance to gamma-radiation by preventing radiation-induced apoptosis; required for tumor prevention;

S122-p - ER-alpha (mouse)
Modsite: LHPPPQLsPFLHPHG SwissProt Entrez-Gene
Orthologous residues
ER‑alpha (human): S118‑p, ER‑alpha (mouse): S122‑p, ER‑alpha (rat): S123‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BRCA1 (mouse) increase in BRCA1 S1152A mutant

S23-p - p53 (mouse)
Modsite: PLsQEtFsGLWKLLP SwissProt Entrez-Gene
Orthologous residues
p53 (human): S20‑p, p53 iso2 (human): S20‑p, p53 iso4 (human): , p53 (mouse): S23‑p, p53 iso2 (mouse): S23‑p, p53 (rat): S20‑p, p53 (rabbit): S20‑p, p53 (green monkey): S20‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase
ionizing_radiation BRCA1 (mouse) inhibit treatment-induced increase delayed increase in BRCA1 S1152A mutant