Curated Information
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Home > Curated Information Page > PubMed Id: 17599050
Runeberg-Roos P, Virtanen H, Saarma M (2007) RET(MEN 2B) is active in the endoplasmic reticulum before reaching the cell surface. Oncogene 26, 7909-15 17599050
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y905-p - Ret (human)
Modsite: DVyEEDsyVKRsQGR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y905‑p, Ret iso2 (human): Y905‑p, Ret iso3 (human): Y429‑p, Ret (mouse): Y906‑p, Ret iso2 (mouse): Y906‑p, Ret iso4 (mouse): , Ret (rat): Y906‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  rat
Comments:  PC6-3 cells (a PC12 cell variant)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase in WT only (RET MEN2B is upregulated and constitutive). variant protein M918T associated with MEN 2B syndrome.

Y1062-p - Ret (human)
Modsite: TWIENkLyGMsDPNW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1062‑p, Ret iso2 (human): Y1062‑p, Ret iso3 (human): Y586‑p, Ret (mouse): Y1063‑p, Ret iso2 (mouse): Y1063‑p, Ret iso4 (mouse): , Ret (rat): Y1063‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  rat
Comments:  PC6-3 cells (a PC12 cell variant)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase in WT only (RET MEN2B is upregulated and constitutive). variant protein M918T associated with MEN 2B syndrome.

Y1096-p - Ret (human)
Modsite: RyPNDSVyANWMLSP SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1096‑p, Ret iso2 (human): , Ret iso3 (human): , Ret (mouse): Y1097‑p, Ret iso2 (mouse): , Ret iso4 (mouse): , Ret (rat): Y1097‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  rat
Comments:  PC6-3 cells (a PC12 cell variant)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GDNF increase in WT only (RET MEN2B is upregulated and constitutive). variant protein M918T associated with MEN 2B syndrome.