Curated Information
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Home > Curated Information Page > PubMed Id: 19919693
Wang M, Sun H, Zhang W, Zhang Y (2009) Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. BMC Musculoskelet Disord 10, 141 19919693
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y402-p - Pyk2 (human)
Modsite: CsIEsDIyAEIPDEt SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y402‑p, Pyk2 iso2 (human): Y402‑p, Pyk2 (mouse): Y402‑p, Pyk2 (rat): Y402‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  rheumatoid arthritis, SLE
Relevant cell lines - cell types - tissues:  mononuclear
Cellular systems studied:  primary cells
Species studied:  human
Comments:  PBMC
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester increase greater increase in SLE patients than RA patients or healthy controls
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced