Shelly M, et al. (2007) LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 129, 565-77 17482549

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T366-p - LKB1 (mouse) ▲

Modsite: IEDGIIytQDFTVPG SwissProt Entrez-Gene Orthologous residues LKB1 (human): T363‑p, LKB1 iso2 (human): T363‑p, LKB1 (mouse): T366‑p, LKB1 (rat): T366‑p, LKB1 (pig): T271‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-'brain, embryonic', HEK293T (epithelial) Cellular systems studied:  cell lines, primary cultured cells Species studied:  rat

S431-p - LKB1 (mouse) ▲

Modsite: sNKIRRLsACKQQ__ SwissProt Entrez-Gene Orthologous residues LKB1 (human): S428‑p, LKB1 iso2 (human): ‑, LKB1 (mouse): S431‑p, LKB1 (rat): S431‑p, LKB1 (pig): S339‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-'brain, embryonic', HEK293T (epithelial) Cellular systems studied:  cell lines, primary cultured cells Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes colforsin increase BDNF increase rolipram increase KT5720 rolipram inhibit treatment-induced increase Downstream Regulation Effect of modification (process):  cell differentiation, induced Comments:  S431A mutation reduced the number of neurons with multiple axons and increased the number of neurons with no axons