Curated Information
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Home > Curated Information Page > PubMed Id: 17482549
Shelly M, et al. (2007) LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 129, 565-77 17482549
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T366-p - LKB1 (mouse)
Modsite: IEDGIIytQDFTVPG SwissProt Entrez-Gene
Orthologous residues
LKB1 (human): T363‑p, LKB1 iso2 (human): T363‑p, LKB1 (mouse): T366‑p, LKB1 (rat): T366‑p, LKB1 (pig): T271‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-'brain, embryonic', HEK293T (epithelial)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  rat

S431-p - LKB1 (mouse)
Modsite: sNKIRRLsACKQQ__ SwissProt Entrez-Gene
Orthologous residues
LKB1 (human): S428‑p, LKB1 iso2 (human): , LKB1 (mouse): S431‑p, LKB1 (rat): S431‑p, LKB1 (pig): S339‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-'brain, embryonic', HEK293T (epithelial)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
colforsin increase
BDNF increase
rolipram increase
KT5720 rolipram inhibit treatment-induced increase
Downstream Regulation
Effect of modification (process):  cell differentiation, induced
Comments:  S431A mutation reduced the number of neurons with multiple axons and increased the number of neurons with no axons