Curated Information
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Home > Curated Information Page > PubMed Id: 16602692
Wang Y, et al. (2006) Proteomic analysis reveals novel molecules involved in insulin signaling pathway. J Proteome Res 5, 846-55 16602692
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y343-p - ANGPT1 (rat)
Modsite: FQRGWKEyKMGFGNP SwissProt Entrez-Gene
Orthologous residues
ANGPT1 (human): Y344‑p, ANGPT1 (mouse): Y344‑p, ANGPT1 (rat): Y343‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y249-p - ANO6 (rat)
Modsite: RLVSSGIyKAAFPLH GenPept Entrez-Gene
Orthologous residues
ANO6 (human): Y241‑p, ANO6 iso2 (human): Y262‑p, ANO6 (mouse): Y242‑p, ANO6 (rat): Y249‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y508-p - ARHGAP24 (rat)
Modsite: MSWLPNGyVTLRDNK SwissProt Entrez-Gene
Orthologous residues
ARHGAP24 (human): Y508‑p, ARHGAP24 (mouse): Y507‑p, ARHGAP24 (rat): Y508‑p
Characterization
Methods used to characterize site in vivo flow cytometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y413-p - BAZ2B (rat)
Modsite: NQAKKEPyRKLVVPS GenPept Entrez-Gene
Orthologous residues
BAZ2B (human): Y398‑p, BAZ2B iso2 (human): Y396‑p, BAZ2B (mouse): Y351‑p, BAZ2B iso3 (mouse): Y414‑p, BAZ2B (rat): Y413‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y644-p - BBS2 (rat)
Modsite: MKTMKTRyMELyDLN SwissProt Entrez-Gene
Orthologous residues
BBS2 (human): Y644‑p, BBS2 (mouse): Y644‑p, BBS2 (rat): Y644‑p
Characterization
Methods used to characterize site in vivo flow cytometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y648-p - BBS2 (rat)
Modsite: KTRyMELyDLNKDLL SwissProt Entrez-Gene
Orthologous residues
BBS2 (human): Y648‑p, BBS2 (mouse): Y648‑p, BBS2 (rat): Y648‑p
Characterization
Methods used to characterize site in vivo flow cytometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y48-p - CDK10 (rat)
Modsite: NRIGEGTyGIVyRAR SwissProt Entrez-Gene
Orthologous residues
CDK10 (human): Y50‑p, CDK10 iso4 (human): , CDK10 (mouse): Y50‑p, CDK10 (rat): Y48‑p
Characterization
Methods used to characterize site in vivo flow cytometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y52-p - CDK10 (rat)
Modsite: EGTyGIVyRARDTQT SwissProt Entrez-Gene
Orthologous residues
CDK10 (human): Y54‑p, CDK10 iso4 (human): , CDK10 (mouse): Y54‑p, CDK10 (rat): Y52‑p
Characterization
Methods used to characterize site in vivo flow cytometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y862-p - CEP290 (rat)
Modsite: DAVKVKEyNNLLNAL SwissProt Entrez-Gene
Orthologous residues
CEP290 (human): Y861‑p, CEP290 (mouse): Y855‑p, CEP290 (rat): Y862‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y139-p - CLEC4E (rat)
Modsite: KPRKKEFyIGLTDQV SwissProt Entrez-Gene
Orthologous residues
CLEC4E (human): F138‑p, CLEC4E (mouse): Y138‑p, CLEC4E (rat): Y139‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y291-p - CLPTM1 (rat)
Modsite: YWNLQKDyyPINESL SwissProt Entrez-Gene
Orthologous residues
CLPTM1 (human): Y291‑p, CLPTM1 (mouse): Y291‑p, CLPTM1 (rat): Y291‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y292-p - CLPTM1 (rat)
Modsite: WNLQKDyyPINESLA SwissProt Entrez-Gene
Orthologous residues
CLPTM1 (human): Y292‑p, CLPTM1 (mouse): Y292‑p, CLPTM1 (rat): Y292‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y54-p - EIF1 (rat)
Modsite: VQGIADDyDKKKLVK SwissProt Entrez-Gene
Orthologous residues
EIF1 (human): Y54‑p, EIF1 (mouse): Y54‑p, EIF1 (rat): Y54‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y471-p - GAN (rat)
Modsite: CGVAMELyVFGGVRS GenPept Entrez-Gene
Orthologous residues
GAN (human): Y471‑p, GAN (mouse): Y471‑p, GAN (rat): Y471‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y26-p - IFITM2 (rat)
Modsite: YETIKEEyGVTELGE SwissProt Entrez-Gene
Orthologous residues
IFITM2 (human): Q26‑p, IFITM2 (mouse): Y26‑p, IFITM2 (rat): Y26‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y27-p - IFITM3 (rat)
Modsite: YERIKEEyEVSELGA SwissProt Entrez-Gene
Orthologous residues
IFITM3 (human): H27‑p, IFITM3 (mouse): Y27‑p, IFITM3 (rat): Y27‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y269-p - INTU (rat)
Modsite: KLTFENAyAVKKETA SwissProt Entrez-Gene
Orthologous residues
INTU (human): Y265‑p, INTU (mouse): Y269‑p, INTU (rat): Y269‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y852-p - ITGA1 (rat)
Modsite: KNKGDSAyNTRTVVQ SwissProt Entrez-Gene
Orthologous residues
ITGA1 (human): Y853‑p, ITGA1 (mouse): Y852‑p, ITGA1 (rat): Y852‑p
Characterization
Methods used to characterize site in vivo flow cytometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y128-p - LOC685989 (rat)
Modsite: LKKEINFyRKLHSRL GenPept Entrez-Gene
Orthologous residues
LOC685989 (rat): Y128‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y269-p - OTOF (rat)
Modsite: SAGRPMDyQVSITVI SwissProt Entrez-Gene
Orthologous residues
OTOF (human): Y254‑p, OTOF iso2 (human): , OTOF iso3 (human): , OTOF (mouse): Y253‑p, OTOF (rat): Y269‑p
Characterization
Methods used to characterize site in vivo phosphoamino acid analysis
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y117-p - PCDHGA5 (rat)
Modsite: VENKMKIyEVEVEVL SwissProt Entrez-Gene
Orthologous residues
PCDHGA5 (human): Y117‑p, PCDHGA5 (mouse): Y117‑p, PCDHGA5 (rat): Y117‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y44-p - PLEKHO1 (rat)
Modsite: REIWKNRyVVLKGDQ SwissProt Entrez-Gene
Orthologous residues
PLEKHO1 (human): Y45‑p, PLEKHO1 (mouse): Y44‑p, PLEKHO1 (rat): Y44‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y53-p - PLEKHO1 (rat)
Modsite: VLKGDQLyVSEKEVK SwissProt Entrez-Gene
Orthologous residues
PLEKHO1 (human): Y54‑p, PLEKHO1 (mouse): Y53‑p, PLEKHO1 (rat): Y53‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y141-p - PMM2 (rat)
Modsite: QEERIEFyELDkKEH SwissProt Entrez-Gene
Orthologous residues
PMM2 (human): Y145‑p, PMM2 (mouse): Y141‑p, PMM2 (rat): Y141‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y132-p - rCG35858 (rat)
Modsite: WIRTGVPySFSQAKK GenPept
Orthologous residues
rCG35858 (rat): Y132‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y436-p - SHPS1 (rat)
Modsite: NDINDITyADLNLPK SwissProt Entrez-Gene
Orthologous residues
SHPS1 (human): Y429‑p, SHPS1 iso2 (human): Y433‑p, SHPS1 iso4 (human): Y428‑p, SHPS1 (mouse): Y440‑p, SHPS1 iso2 (mouse): Y436‑p, SHPS1 (rat): Y436‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y477-p - SHPS1 (rat)
Modsite: RPEDtLTyADLDMVH SwissProt Entrez-Gene
Orthologous residues
SHPS1 (human): Y470‑p, SHPS1 iso2 (human): Y474‑p, SHPS1 iso4 (human): Y469‑p, SHPS1 (mouse): Y481‑p, SHPS1 iso2 (mouse): Y477‑p, SHPS1 (rat): Y477‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y577-p - skMLCK (rat)
Modsite: SQILLKKyLMKRRWK SwissProt Entrez-Gene
Orthologous residues
skMLCK (human): Y563‑p, skMLCK (mouse): Y580‑p, skMLCK (rat): Y577‑p, skMLCK (rabbit): Y575‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y836-p - SNX13 (rat)
Modsite: RKKDLNAyLQLLLTP GenPept Entrez-Gene
Orthologous residues
SNX13 (human): Y660‑p, SNX13 (mouse): Y649‑p, SNX13 (rat): Y836‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y419-p - Src (rat)
Modsite: RLIEDNEyTARQGAk SwissProt Entrez-Gene
Orthologous residues
Src (human): Y419‑p, Src iso2 (human): Y425‑p, Src (mouse): Y418‑p, Src iso1 (mouse): Y424‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y720-p - THNSL1 (rat)
Modsite: KQKGKMDyQACVADV SwissProt Entrez-Gene
Orthologous residues
THNSL1 (human): Y720‑p, THNSL1 (mouse): Y720‑p, THNSL1 (rat): Y720‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat

Y1030-p - UBE3C (rat)
Modsite: LLGFKELyPAFCIHN GenPept Entrez-Gene
Orthologous residues
UBE3C (human): Y1030‑p, UBE3C (mouse): Y1030‑p, UBE3C (rat): Y1030‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y229-p - Vmn2r1 (rat)
Modsite: SETIPKVySNEKMQK SwissProt Entrez-Gene
Orthologous residues
Vmn2r1 (mouse): Y259‑p, Vmn2r1 (rat): Y229‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y139-p - XIAP (rat)
Modsite: PSETHADyLLRTGQV SwissProt Entrez-Gene
Orthologous residues
XIAP (human): Y139‑p, XIAP (mouse): Y139‑p, XIAP (rat): Y139‑p
Characterization
Methods used to characterize site in vivo flow cytometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y424-p - Yes (rat)
Modsite: RLIEDNEyTARQGAk SwissProt Entrez-Gene
Orthologous residues
Yes (human): Y426‑p, Yes (mouse): Y424‑p, Yes (rat): Y424‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase