Curated Information
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Home > Curated Information Page > PubMed Id: 17403678
Mitchell D, et al. (2007) The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases. J Biol Chem 282, 15606-18 17403678
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y740-p - PDGFRB (human)
Modsite: TGESDGGyMDMSKDE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y740‑p, PDGFRB (mouse): Y739‑p, PDGFRB (rat): Y739‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3C2A (human) Induces phosphorylation

Y751-p - PDGFRB (human)
Modsite: SKDESVDyVPMLDMK SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y751‑p, PDGFRB (mouse): Y750‑p, PDGFRB (rat): Y750‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3C2A (human) Induces phosphorylation

Y763-p - PDGFRB (human)
Modsite: DMKGDVKyADIESSN SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y763‑p, PDGFRB (mouse): Y762‑p, PDGFRB (rat): Y762‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces phosphorylation

Y1009-p - PDGFRB (human)
Modsite: LDTSSVLyTAVQPNE SwissProt Entrez-Gene
Orthologous residues
PDGFRB (human): Y1009‑p, PDGFRB (mouse): Y1008‑p, PDGFRB (rat): Y1008‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces phosphorylation