Li P, et al. (2008) Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts. Circ Res 102, 185-92 17991884

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S309-p - SMAD3 (mouse) ▲

Modsite: EVFAECLsDSAIFVQ SwissProt Entrez-Gene Orthologous residues SMAD3 (human): S309‑p, SMAD3 (mouse): S309‑p, SMAD3 (rat): S309‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, western blotting Relevant cell lines - cell types - tissues:  heart Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKG1 (mouse) inhibition of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TGF-beta increase KT5823 decrease Downstream Regulation Effect of modification (function):  activity, induced, intracellular localization Comments:  Nuclear translocation

T388-p - SMAD3 (mouse) ▲

Modsite: GAEYRRQtVTSTPCW SwissProt Entrez-Gene Orthologous residues SMAD3 (human): T388‑p, SMAD3 (mouse): T388‑p, SMAD3 (rat): T388‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, western blotting Relevant cell lines - cell types - tissues:  heart Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKG1 (mouse) inhibition of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TGF-beta increase KT5823 decrease Downstream Regulation Effect of modification (function):  activity, induced, intracellular localization Comments:  Nuclear translocation