Curated Information
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Home > Curated Information Page > PubMed Id: 17854274
Harraz MM, et al. (2007) MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity. Antioxid Redox Signal 9, 1803-13 17854274
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y219-p - MKK6 (human)
Modsite: IDAGCKPyMAPERIN SwissProt Entrez-Gene
Orthologous residues
MKK6 (human): Y219‑p, MKK6 iso2 (human): Y163‑p, MKK6 (mouse): Y219‑p, MKK6 (rat): Y219‑p
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RAW 264 (macrophage)
Cellular systems studied:  cell lines
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE MKK6 (human)
Comments:  constitutively active mutant of MKK6 (S207A/T211E) used
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAC1 (human) Induces enzymatic activity, induced in vitro
Comments:  enhances Rac-GTPase activity and inhibits NADPH oxidase activity in vivo