Harraz MM, et al. (2007) MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity. Antioxid Redox Signal 9, 1803-13 17854274

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Y219-p - MKK6 (human) ▲

Modsite: IDAGCKPyMAPERIN SwissProt Entrez-Gene Orthologous residues MKK6 (human): Y219‑p, MKK6 iso2 (human): Y163‑p, MKK6 (mouse): Y219‑p, MKK6 (rat): Y219‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  RAW 264 (macrophage) Cellular systems studied:  cell lines Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE MKK6 (human) Comments:  constitutively active mutant of MKK6 (S207A/T211E) used Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays RAC1 (human) Induces enzymatic activity, induced in vitro Comments:  enhances Rac-GTPase activity and inhibits NADPH oxidase activity in vivo