Curated Information
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Home > Curated Information Page > PubMed Id: 17434132
Hao B, et al. (2007) Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol Cell 26, 131-43 17434132
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T77-p - CCNE1 (human)
Modsite: DPCsLIPtPDKEDDD SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T77‑p, CCNE1 (mouse): T74‑p, CCNE1 (rat): T77‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBXW7 (human) WD40 Induces in vitro

T395-p - CCNE1 (human)
Modsite: PLPSGLLtPPQsGKK SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): T395‑p, CCNE1 (mouse): T393‑p, CCNE1 (rat): T396‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein degradation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBXW7 (human) WD40 Induces in vitro

S399-p - CCNE1 (human)
Modsite: GLLtPPQsGKKQSSG SwissProt Entrez-Gene
Orthologous residues
CCNE1 (human): S399‑p, CCNE1 (mouse): S397‑p, CCNE1 (rat): S400‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein degradation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBXW7 (human) WD40 Induces in vitro