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Home > Curated Information Page > PubMed Id: 28592492
Kim HJ, et al. (2017) Heterogeneous nuclear ribonucleoprotein K inhibits heat shock-induced transcriptional activity of heat shock factor 1. J Biol Chem 292, 12801-12812 28592492
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S36-p - hnRNP K (mouse)
Modsite: EEQAFkRsRNtDEMV SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): S36‑p, hnRNP K iso2 (human): S36‑p, hnRNP K iso3 (human): S36‑p, hnRNP K (mouse): S36‑p, hnRNP K iso2 (mouse): S36‑p, hnRNP K iso3 (mouse): S36‑p, hnRNP K iso4 (mouse): S36‑p, hnRNP K (rat): S36‑p, hnRNP K (cow): S36‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

K52-ac - hnRNP K (mouse)
Modsite: LRILLQSkNAGAVIG SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): K52‑ac, hnRNP K iso2 (human): K52‑ac, hnRNP K iso3 (human): K52‑ac, hnRNP K (mouse): K52‑ac, hnRNP K iso2 (mouse): K52‑ac, hnRNP K iso3 (mouse): K52‑ac, hnRNP K iso4 (mouse): K52‑ac, hnRNP K (rat): K52‑ac, hnRNP K (cow): K52‑ac
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

T70-p - hnRNP K (mouse)
Modsite: KNIkALRtDyNAsVs SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): T70‑p, hnRNP K iso2 (human): T70‑p, hnRNP K iso3 (human): T70‑p, hnRNP K (mouse): T70‑p, hnRNP K iso2 (mouse): T70‑p, hnRNP K iso3 (mouse): T70‑p, hnRNP K iso4 (mouse): T70‑p, hnRNP K (rat): T70‑p, hnRNP K (cow): T70‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease

Y72-p - hnRNP K (mouse)
Modsite: IkALRtDyNAsVsVP SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): Y72‑p, hnRNP K iso2 (human): Y72‑p, hnRNP K iso3 (human): Y72‑p, hnRNP K (mouse): Y72‑p, hnRNP K iso2 (mouse): Y72‑p, hnRNP K iso3 (mouse): Y72‑p, hnRNP K iso4 (mouse): Y72‑p, hnRNP K (rat): Y72‑p, hnRNP K (cow): Y72‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease

S89-p - hnRNP K (mouse)
Modsite: SGPERILsIsADIEt SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): S89‑p, hnRNP K iso2 (human): S89‑p, hnRNP K iso3 (human): S89‑p, hnRNP K (mouse): S89‑p, hnRNP K iso2 (mouse): S89‑p, hnRNP K iso3 (mouse): S89‑p, hnRNP K iso4 (mouse): S89‑p, hnRNP K (rat): S89‑p, hnRNP K (cow): S89‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease

S91-p - hnRNP K (mouse)
Modsite: PERILsIsADIEtIG SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): S91‑p, hnRNP K iso2 (human): S91‑p, hnRNP K iso3 (human): S91‑p, hnRNP K (mouse): S91‑p, hnRNP K iso2 (mouse): S91‑p, hnRNP K iso3 (mouse): S91‑p, hnRNP K iso4 (mouse): S91‑p, hnRNP K (rat): S91‑p, hnRNP K (cow): S91‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease

T107-p - hnRNP K (mouse)
Modsite: ILKKIIPtLEEGLQL SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): T107‑p, hnRNP K iso2 (human): T107‑p, hnRNP K iso3 (human): T107‑p, hnRNP K (mouse): T107‑p, hnRNP K iso2 (mouse): T107‑p, hnRNP K iso3 (mouse): T107‑p, hnRNP K iso4 (mouse): T107‑p, hnRNP K (rat): T107‑p, hnRNP K (cow): T107‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

S116-p - hnRNP K (mouse)
Modsite: EEGLQLPsPtAtsQL SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): S116‑p, hnRNP K iso2 (human): S116‑p, hnRNP K iso3 (human): , hnRNP K (mouse): S116‑p, hnRNP K iso2 (mouse): S116‑p, hnRNP K iso3 (mouse): , hnRNP K iso4 (mouse): , hnRNP K (rat): S116‑p, hnRNP K (cow): S116‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

S154-p - hnRNP K (mouse)
Modsite: LRLLIHQsLAGGIIG SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): S154‑p, hnRNP K iso2 (human): S154‑p, hnRNP K iso3 (human): S130‑p, hnRNP K (mouse): S154‑p, hnRNP K iso2 (mouse): S154‑p, hnRNP K iso3 (mouse): S130‑p, hnRNP K iso4 (mouse): S130‑p, hnRNP K (rat): S154‑p, hnRNP K (cow): S154‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

K198-ac - hnRNP K (mouse)
Modsite: RVVLIGGkPDRVVEC SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): K198‑ac, hnRNP K iso2 (human): K198‑ac, hnRNP K iso3 (human): K174‑ac, hnRNP K (mouse): K198‑ac, hnRNP K iso2 (mouse): K198‑ac, hnRNP K iso3 (mouse): K174‑ac, hnRNP K iso4 (mouse): K174‑ac, hnRNP K (rat): K198‑ac, hnRNP K (cow): K198‑ac
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

K219-ac - hnRNP K (mouse)
Modsite: LISEsPIkGRAQPYD SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): K219‑ac, hnRNP K iso2 (human): K219‑ac, hnRNP K iso3 (human): K195‑ac, hnRNP K (mouse): K219‑ac, hnRNP K iso2 (mouse): K219‑ac, hnRNP K iso3 (mouse): K195‑ac, hnRNP K iso4 (mouse): K195‑ac, hnRNP K (rat): K219‑ac, hnRNP K (cow): K219‑ac
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

R316-m1 - hnRNP K (mouse)
Modsite: LPPPPPPrGGDLMAy SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): R316‑m1, hnRNP K iso2 (human): R316‑m1, hnRNP K iso3 (human): R292‑m1, hnRNP K (mouse): R316‑m1, hnRNP K iso2 (mouse): R316‑m1, hnRNP K iso3 (mouse): R292‑m1, hnRNP K iso4 (mouse): R292‑m1, hnRNP K (rat): R316‑m1, hnRNP K (cow): R316‑m1
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

S379-p - hnRNP K (mouse)
Modsite: SYAGGrGsyGDLGGP SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): S379‑p, hnRNP K iso2 (human): S379‑p, hnRNP K iso3 (human): S355‑p, hnRNP K (mouse): S379‑p, hnRNP K iso2 (mouse): S379‑p, hnRNP K iso3 (mouse): S355‑p, hnRNP K iso4 (mouse): S355‑p, hnRNP K (rat): S379‑p, hnRNP K (cow): S379‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

K405-ac - hnRNP K (mouse)
Modsite: LAGSIIGkGGQRIKQ SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): K405‑ac, hnRNP K iso2 (human): K405‑ac, hnRNP K iso3 (human): K381‑ac, hnRNP K (mouse): K405‑ac, hnRNP K iso2 (mouse): K405‑ac, hnRNP K iso3 (mouse): K381‑ac, hnRNP K iso4 (mouse): K381‑ac, hnRNP K (rat): K405‑ac, hnRNP K (cow): K405‑ac
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse

T436-p - hnRNP K (mouse)
Modsite: GsEDRIItITGtQDQ SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): T436‑p, hnRNP K iso2 (human): T436‑p, hnRNP K iso3 (human): T412‑p, hnRNP K (mouse): T436‑p, hnRNP K iso2 (mouse): T436‑p, hnRNP K iso3 (mouse): T412‑p, hnRNP K iso4 (mouse): T412‑p, hnRNP K (rat): T436‑p, hnRNP K (cow): T436‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease

T440-p - hnRNP K (mouse)
Modsite: RIItITGtQDQIQNA SwissProt Entrez-Gene
Orthologous residues
hnRNP K (human): T440‑p, hnRNP K iso2 (human): T440‑p, hnRNP K iso3 (human): T416‑p, hnRNP K (mouse): T440‑p, hnRNP K iso2 (mouse): T440‑p, hnRNP K iso3 (mouse): T416‑p, hnRNP K iso4 (mouse): T416‑p, hnRNP K (rat): T440‑p, hnRNP K (cow): T440‑p
Characterization
Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease