Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 19833152
Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW (2009) Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35. Biochim Biophys Acta 1793, 1860-7 19833152
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S19-p - TH iso3 (human)
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
colforsin no change compared to control
muscarine increase
U0126 no change compared to control
EGF no change compared to control

S31-p - TH iso3 (human)
Modsite: KQAEAIMsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
colforsin no change compared to control
muscarine no change compared to control
EGF increase
U0126 decrease
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  stimulates phosphorylation of S40 in TH iso2

S40-p - TH iso3 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
colforsin increase
muscarine increase
EGF no change compared to control
U0126 decrease

S19-p - TH iso4 (human)
Modsite: KGFRRAVsELDAKQA SwissProt Entrez-Gene
Orthologous residues
TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
colforsin no change compared to control
muscarine increase
U0126 no change compared to control
EGF no change compared to control

S35-p - TH iso4 (human)
Modsite: AIMVRGQsPRFIGRR SwissProt Entrez-Gene
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p

S44-p - TH iso4 (human)
Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
colforsin increase
muscarine increase
EGF no change compared to control
U0126 no change compared to control