Procida K, et al. (2009) Phosphorylation of connexin43 on serine 306 regulates electrical coupling. Heart Rhythm 6, 1632-8 19879542

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S296-p - GJA1 (rat) ▲

Modsite: VTGDRNNssCRNYNk SwissProt Entrez-Gene Orthologous residues GJA1 (human): S296‑p, GJA1 (mouse): S296‑p, GJA1 (rat): S296‑p, GJA1 (rabbit): S296‑p, GJA1 (pig): S296‑p, GJA1 (hamster): S296‑p, GJA1 (cow): S297‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human

S297-p - GJA1 (rat) ▲

Modsite: TGDRNNssCRNYNkQ SwissProt Entrez-Gene Orthologous residues GJA1 (human): S297‑p, GJA1 (mouse): S297‑p, GJA1 (rat): S297‑p, GJA1 (rabbit): S297‑p, GJA1 (pig): S297‑p, GJA1 (hamster): S297‑p, GJA1 (cow): S298‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human

S306-p - GJA1 (rat) ▲

Modsite: RNYNkQAsEQNWANy SwissProt Entrez-Gene Orthologous residues GJA1 (human): S306‑p, GJA1 (mouse): S306‑p, GJA1 (rat): S306‑p, GJA1 (rabbit): S306‑p, GJA1 (pig): S306‑p, GJA1 (hamster): S306‑p, GJA1 (cow): S307‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  heart, HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human, rat Downstream Regulation Effect of modification (function):  activity, induced Comments:  mutation of this site decreases single channel conductance and gating