Curated Information
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Home > Curated Information Page > PubMed Id: 19864431
Foster KG, et al. (2010) Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem 285, 80-94 19864431
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S696-p - Raptor (human)
Modsite: EKNyALPsPAttEGG SwissProt Entrez-Gene
Orthologous residues
Raptor (human): S696‑p, Raptor (mouse): S696‑p, Raptor (rat): S696‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
RHEB (human) increase

T706-p - Raptor (human)
Modsite: ttEGGsLtPVRDsPC SwissProt Entrez-Gene
Orthologous residues
Raptor (human): T706‑p, Raptor (mouse): T706‑p, Raptor (rat): T706‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
RHEB (human) increase

S855-p - Raptor (human)
Modsite: QRVLDtssLtQsAPA SwissProt Entrez-Gene
Orthologous residues
Raptor (human): S855‑p, Raptor (mouse): S855‑p, Raptor (rat): S855‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
RHEB (human) increase

S859-p - Raptor (human)
Modsite: DtssLtQsAPAsPtN SwissProt Entrez-Gene
Orthologous residues
Raptor (human): S859‑p, Raptor (mouse): S859‑p, Raptor (rat): S859‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
RHEB (human) increase

S863-p - Raptor (human)
Modsite: LtQsAPAsPtNkGVH SwissProt Entrez-Gene
Orthologous residues
Raptor (human): S863‑p, Raptor (mouse): S863‑p, Raptor (rat): S863‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
wortmannin insulin inhibit treatment-induced increase
rapamycin insulin inhibit treatment-induced increase
amino_acid_starvation insulin inhibit treatment-induced increase
serum increase
phorbol_ester increase
EGF increase
U0126 EGF inhibit treatment-induced increase
RHEB (human) increase
rapamycin RHEB (human) inhibit treatment-induced increase
TSC1 (human) decrease
amino_acid_starvation, insulin decrease
amino_acids increase
rapamycin amino_acids inhibit treatment-induced increase
2-deoxyglucose decrease
RHEB (human) increase
Downstream Regulation
Effect of modification (function):  activity, induced, phosphorylation
Comments:  required for Rheb-stimulated phosphorylation of S855 and S859

S877-p - Raptor (human)
Modsite: HIHQAGGsPPAssts SwissProt Entrez-Gene
Orthologous residues
Raptor (human): S877‑p, Raptor (mouse): S877‑p, Raptor (rat): S877‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
RHEB (human) increase

S863-p - Raptor (mouse)
Modsite: LtQsAPAsPtNKGMH SwissProt Entrez-Gene
Orthologous residues
Raptor (human): S863‑p, Raptor (mouse): S863‑p, Raptor (rat): S863‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
wortmannin insulin inhibit treatment-induced increase
rapamycin insulin inhibit treatment-induced increase