Pilankatta R, Lewis D, Adams CM, Inesi G (2009) High yield heterologous expression of wild-type and mutant Cu+-ATPase (ATP7B, Wilson disease protein) for functional characterization of catalytic activity and serine residues undergoing copper-dependent phosphorylation. J Biol Chem 284, 21307-16 19520855

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S478-p - ATP7B (human) ▲

Modsite: APDILAKsPQsTRAV SwissProt Entrez-Gene Orthologous residues ATP7B (human): S478‑p, ATP7B iso2 (human): S478‑p, ATP7B (mouse): T480‑p, ATP7B (rat): S471‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mass spectrometry (in vitro) Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes copper increase

S481-p - ATP7B (human) ▲

Modsite: ILAKsPQsTRAVAPQ SwissProt Entrez-Gene Orthologous residues ATP7B (human): S481‑p, ATP7B iso2 (human): S481‑p, ATP7B (mouse): S483‑p, ATP7B (rat): S474‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mass spectrometry (in vitro) Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes copper increase

S1121-p - ATP7B (human) ▲

Modsite: AHSERPLsAPASHLN SwissProt Entrez-Gene Orthologous residues ATP7B (human): S1121‑p, ATP7B iso2 (human): S914‑p, ATP7B (mouse): ‑, ATP7B (rat): ‑ Characterization Methods used to characterize site in vivo:  mass spectrometry, mass spectrometry (in vitro) Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes copper increase

S1453-p - ATP7B (human) ▲

Modsite: DDDGDKWsLLLNGRD SwissProt Entrez-Gene Orthologous residues ATP7B (human): S1453‑p, ATP7B iso2 (human): S1246‑p, ATP7B (mouse): S1450‑p, ATP7B (rat): S1439‑p Characterization Methods used to characterize site in vivo:  mass spectrometry, mass spectrometry (in vitro) Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes copper increase