Emdal KB, et al. (2018) Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma. Sci Signal 11 30459283

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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Y1078-p - ALK (human) ▲
Modsite: MELQsPEyKLSKLRT SwissProt Entrez-Gene Orthologous residues ALK (human): Y1078‑p, ALK (mouse): Y1082‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human

Y1092-p - ALK (human) ▲
Modsite: TSTIMtDyNPNyCFA SwissProt Entrez-Gene Orthologous residues ALK (human): Y1092‑p, ALK (mouse): Y1096‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human

Y1096-p - ALK (human) ▲

Modsite: MtDyNPNyCFAGKTS SwissProt Entrez-Gene Orthologous residues ALK (human): Y1096‑p, ALK (mouse): Y1100‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays IRS2 (human) Induces in vitro

Y1131-p - ALK (human) ▲
Modsite: HGAFGEVyEGQVSGM SwissProt Entrez-Gene Orthologous residues ALK (human): Y1131‑p, ALK (mouse): Y1135‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human

Y1278-p - ALK (human) ▲
Modsite: FGMARDIyRAsyyRK SwissProt Entrez-Gene Orthologous residues ALK (human): Y1278‑p, ALK (mouse): Y1282‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human

Y1283-p - ALK (human) ▲
Modsite: DIyRAsyyRKGGCAM SwissProt Entrez-Gene Orthologous residues ALK (human): Y1283‑p, ALK (mouse): Y1287‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human

Y1359-p - ALK (human) ▲
Modsite: KNCPGPVyRIMTQCW SwissProt Entrez-Gene Orthologous residues ALK (human): Y1359‑p, ALK (mouse): Y1363‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human

Y1507-p - ALK (human) ▲

Modsite: TSLWNPtyGsWFTEK SwissProt Entrez-Gene Orthologous residues ALK (human): Y1507‑p, ALK (mouse): Y1516‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SHC3 (human) PTB Induces in vitro SHC1 (human) PTB Not reported in vitro IRS2 (human) Induces in vitro

Y1584-p - ALK (human) ▲

Modsite: FPCGNVNyGyQQQGL SwissProt Entrez-Gene Orthologous residues ALK (human): Y1584‑p, ALK (mouse): Y1590‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays IRS2 (human) Induces in vitro

Y1604-p - ALK (human) ▲

Modsite: tAPGAGHyEDTILkS SwissProt Entrez-Gene Orthologous residues ALK (human): Y1604‑p, ALK (mouse): ‑ Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma, neuroblastoma Relevant cell lines - cell types - tissues:  NCI-H3122 (pulmonary), SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes NVP-TAE684 decrease crizotinib decrease ceritinib decrease U0126 decrease LY294002 decrease

Y675-p - IRS2 (human) ▲

Modsite: GSCRsDDyMPMsPAs SwissProt Entrez-Gene Orthologous residues IRS2 (human): Y675‑p, IRS2 (mouse): Y671‑p, IRS2 (rat): Y672‑p Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PIK3C2A (human) Induces in vitro

Y742-p - IRS2 (human) ▲
Modsite: ssPEDsGyMRMWCGS SwissProt Entrez-Gene Orthologous residues IRS2 (human): Y742‑p, IRS2 (mouse): Y734‑p, IRS2 (rat): Y735‑p

Y978-p - IRS2 (human) ▲

Modsite: QRsPLsDyMNLDFSS SwissProt Entrez-Gene Orthologous residues IRS2 (human): Y978‑p, IRS2 (mouse): Y970‑p, IRS2 (rat): Y973‑p Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PIK3C2A (human) Induces in vitro