Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.6
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 19741007
Chen L, Salinas GD, Li X (2009) Regulation of serotonin 1B receptor by glycogen synthase kinase-3. Mol Pharmacol 76, 1150-61 19741007
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S154-p - 5-HT(1B) (mouse)
Modsite: ITDAVEYsAKRtPKR SwissProt Entrez-Gene
Orthologous residues
5‑HT(1B) (human): S158‑p, 5‑HT(1B) (mouse): S154‑p, 5‑HT(1B) (rat): S154‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, modification site within consensus motif
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
5-HT increase
SB216763 decrease
Downstream Regulation
Effect of modification (function):  activity, induced, receptor internalization, altered

T158-p - 5-HT(1B) (mouse)
Modsite: VEYsAKRtPKRAAIM SwissProt Entrez-Gene
Orthologous residues
5‑HT(1B) (human): T162‑p, 5‑HT(1B) (mouse): T158‑p, 5‑HT(1B) (rat): T158‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
5-HT increase