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Site Group Page (References Reporting Low Throughput Detection Method)
 

Site Information
NFkB-p65 (human) K310-ac KRTYETFkSIMKKSP 1, 2, 3, 4, 6, 10, 11, 12, 14, 16, 18, 19, 21, 23, 25, 26, 28, 29, 30, 32, 33, 34, 35, 36
NFkB-p65 (mouse) K310-ac KRTYETFkSIMKKSP 5, 7, 8, 9, 13, 15, 20, 22, 24, 27, 31
NFkB-p65 (rat) K310-ac KRTYETFkSIMKKSP 17

References

1

Zou Z, et al. (2014) Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA. Oncogene 33, 2395-404
23686307   Curated Info

2

Sgarbanti M, et al. (2014) IκB Kinase {varepsilon} Targets Interferon Regulatory Factor 1 in Activated T Lymphocytes. Mol Cell Biol 34, 1054-65
24396068   Curated Info

3

Kühnemuth B, et al. (2013) CUX1 modulates polarization of tumor-associated macrophages by antagonizing NF-κB signaling. Oncogene
24336331   Curated Info

4

Wu X, et al. (2013) Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling. J Biol Chem 288, 36094-105
24189064   Curated Info

5

Lin J, et al. (2013) Sirt2 suppresses inflammatory responses in collagen-induced arthritis. Biochem Biophys Res Commun 441, 897-903
24211200   Curated Info

6

Li Y, et al. (2013) Sirt2 suppresses glioma cell growth through targeting NF-κB-miR-21 axis. Biochem Biophys Res Commun 441, 661-7
24161395   Curated Info

7

Pais TF, et al. (2013) The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J 32, 2603-16
24013120   Curated Info

8

Kauppinen TM, Gan L, Swanson RA (2013) Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. Biochim Biophys Acta 1833, 1985-91
23597856   Curated Info

9

Edwards JR, et al. (2013) Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling. J Bone Miner Res 28, 960-9
23172686   Curated Info

10

Gang D, et al. (2013) The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of Sirt1 in hepatocellular carcinoma. Mol Biol Rep 40, 2461-6
23224434   Curated Info

11

Ziesché E, et al. (2013) The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Res 41, 90-109
23087373   Curated Info

12

Ning Z, et al. (2013) The N terminus of orf virus-encoded protein 002 inhibits acetylation of NF-κB p65 by preventing Ser(276) phosphorylation. PLoS One 8, e58854
23536830   Curated Info

13

Sato T, Kotake D, Hiratsuka M, Hirasawa N (2013) Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. PLoS One 8, e59702
23555753   Curated Info

14

Allison DF, et al. (2012) Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription. Proc Natl Acad Sci U S A 109, 16888-93
23027940   Curated Info

15

Kim YJ, et al. (2012) Inhibitory effects of aurentiacin from Syzygium samarangense on lipopolysaccharide-induced inflammatory response in mouse macrophages. Food Chem Toxicol 50, 1027-35
22155221   Curated Info

16

Clavijo PE, Frauwirth KA (2012) Anergic CD8+ T lymphocytes have impaired NF-κB activation with defects in p65 phosphorylation and acetylation. J Immunol 188, 1213-21
22205033   Curated Info

17

Lei M, et al. (2012) Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity. Eur J Pharmacol 674, 73-9
22044919   Curated Info

18

Yang L, et al. (2012) SIRT1 Regulates CD40 Expression Induced by TNF-α via NF-ĸB Pathway in Endothelial Cells. Cell Physiol Biochem 30, 1287-98
23075766   Curated Info

19

Zhang Y, et al. (2011) AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler Thromb Vasc Biol 31, 2897-908
21940946   Curated Info

20

Brasier AR, et al. (2011) RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection. J Virol 85, 11752-69
21900162   Curated Info

21

Breitenstein A, et al. (2011) Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res 89, 464-72
20978007   Curated Info

22

Chandrakesan P, et al. (2010) Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38. J Biol Chem 285, 33485-98
20710027   Curated Info

23

Yang XD, Tajkhorshid E, Chen LF (2010) Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. Mol Cell Biol 30, 2170-80
20160011   Curated Info

24

Rajendrasozhan S, et al. (2010) Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. Am J Physiol Lung Cell Mol Physiol 298, L197-209
19965984   Curated Info

25

Rothgiesser KM, Fey M, Hottiger MO (2010) Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression. BMC Genomics 11, 22
20064247   Curated Info

26

Lee H, et al. (2009) Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15, 283-93
19345327   Curated Info

27

Yoshizaki T, et al. (2009) SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol 29, 1363-74
19103747   Curated Info

28

Huang B, et al. (2009) Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol 29, 1375-87
19103749   Curated Info

29

Buerki C, et al. (2008) Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res 36, 1665-80
18263619   Curated Info

30

Dai Y, et al. (2008) Interactions between Bortezomib and Romidepsin and Belinostat in Chronic Lymphocytic Leukemia Cells. Clin Cancer Res 14, 549-58
18223231   Curated Info

31

Basu S, et al. (2007) Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification. Cell Microbiol 9, 2804-16
17590163   Curated Info

32

Saha RN, Jana M, Pahan K (2007) MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol 179, 7101-9
17982102   Curated Info

33

Singh M, Popowicz GM, Krajewski M, Holak TA (2007) Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex. Chembiochem 8, 1308-16
17582821   Curated Info

34

Ito K (2007) Impact of post-translational modifications of proteins on the inflammatory process. Biochem Soc Trans 35, 281-3
17371260   Curated Info

35

Liu Y, et al. (2006) Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65. J Biol Chem 281, 31359-68
16926151   Curated Info

36

Chen LF, Mu Y, Greene WC (2002) Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 21, 6539-48
12456660   Curated Info

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