Site Group Page (References Reporting Low Throughput Detection Method)
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Site Group Page (References Reporting Low Throughput Detection Method)
 

Site Information
Chk1 (human) S317-p ENVKYSSsQPEPRTG 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28, 29, 30, 31, 33, 34, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57
Chk1 (mouse) S317-p ETVKFSSsQPEPRTG 25, 32, 35, 36
Chk1 (rat) S317-p ENVKFSSsQPEPRTG
Chk1 (chicken) S317-p DKASYSTsQPEPGTG

References

1

Kubota S, et al. (2014) Activation of the Prereplication Complex Is Blocked by Mimosine through Reactive Oxygen Species-activated Ataxia Telangiectasia Mutated (ATM) Protein without DNA Damage. J Biol Chem 289, 5730-46
24421316   Curated Info

2

Penicud K, Behrens A (2014) DMAP1 is an essential regulator of ATM activity and function. Oncogene 33, 525-31
23318425   Curated Info

3

Yamada M, et al. (2013) ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. Genes Dev 27, 2459-72
24240236   Curated Info

4

Couch FB, et al. (2013) ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev 27, 1610-23
23873943   Curated Info

5

Cheng YC, Lin TY, Shieh SY (2013) Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. Proc Natl Acad Sci U S A 110, 5993-8
23533280   Curated Info

6

Chilà R, et al. (2013) Chk1-Mad2 interaction: A crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint. Cell Cycle 12, 1083-90
23454898   Curated Info

7

Sokol AM, Cruet-Hennequart S, Pasero P, Carty MP (2013) DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells. Sci Rep 3, 3277
24253929   Curated Info

8

Sato K, et al. (2012) A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair. Curr Biol 22, 1659-66
22863316   Curated Info

9

Lee AY, et al. (2012) Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem 287, 2531-43
22123827   Curated Info

10

Prendergast ÁM, et al. (2011) Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation. Cell Cycle 10, 3768-77
22037398   Curated Info

11

Nam EA, Zhao R, Cortez D (2011) Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. J Biol Chem 286, 37320-7
21908846   Curated Info

12

Lossaint G, et al. (2011) Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. Oncogene 30, 4261-74
21532626   Curated Info

13

Xu N, Libertini S, Zhang Y, Gillespie DA (2011) Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency. Biochem Biophys Res Commun 413, 465-70
21907702   Curated Info

14

Carlessi L, Buscemi G, Fontanella E, Delia D (2010) A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage. Biochim Biophys Acta 1803, 1213-23
20599567   Curated Info

15

Kasahara K, et al. (2010) 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. EMBO J 29, 2802-12
20639859   Curated Info

16

Yan Y, et al. (2010) Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene 29, 4317-29
20498628   Curated Info

17

Greer Card DA, Sierant ML, Davey S (2010) Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition. J Biol Chem 285, 15653-61
20305300   Curated Info

18

Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG (2010) Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 140, 349-59
20116089   Curated Info

19

Freeman AK, Dapic V, Monteiro AN (2010) Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage. Cell Cycle 9, 736-47
20160490   Curated Info

20

Zhong D, et al. (2009) The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R. J Biol Chem 284, 23225-33
19574224   Curated Info

21

Berglund FM, Clarke PR (2009) hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks. Biochem Biophys Res Commun 381, 59-64
19351595   Curated Info

22

Wilsker D, Petermann E, Helleday T, Bunz F (2008) Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci U S A 105, 20752-7
19091954   Curated Info

23

Ikegami Y, et al. (2008) Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation. Biochem Biophys Res Commun 377, 1227-31
18983824   Curated Info

24

Collis SJ, et al. (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell 32, 313-24
18995830   Curated Info

25

Hitomi M, Yang K, Stacey AW, Stacey DW (2008) Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression. Mol Cell Biol 28, 5478-93
18606783   Curated Info

26

Yan Y, et al. (2008) Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. Cancer Res 68, 5113-21
18593910   Curated Info

27

Petermann E, Helleday T, Caldecott KW (2008) Claspin promotes normal replication fork rates in human cells. Mol Biol Cell 19, 2373-8
18353973   Curated Info

28

Campregher C, Luciani MG, Gasche C (2008) Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. Gut 57, 780-7
18272544   Curated Info

29

Sidi S, et al. (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133, 864-77
18510930   Curated Info

30

Richard DJ, et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453, 677-81
18449195   Curated Info

31

Cruet-Hennequart S, et al. (2008) Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin. DNA Repair (Amst) 7, 582-96
18289945   Curated Info

32

Yang YG, Lindahl T, Barnes DE (2007) Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131, 873-86
18045533   Curated Info

33

Olson E, et al. (2007) The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem 282, 22939-52
17526493   Curated Info

34

Yan Y, Black CP, Cowan KH (2007) Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene 26, 4689-98
17297454   Curated Info

35

Difilippantonio S, et al. (2007) Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med 204, 1003-11
17485521   Curated Info

36

Niida H, et al. (2007) Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol 27, 2572-81
17242188   Curated Info

37

Carlessi L, et al. (2007) Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther 6, 935-44
17363488   Curated Info

38

Stiff T, et al. (2006) ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 25, 5775-82
17124492   Curated Info

39

Chini CC, Chen J (2006) Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem 281, 33276-82
16963448   Curated Info

40

Leung-Pineda V, Ryan CE, Piwnica-Worms H (2006) Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol 26, 7529-38
17015476   Curated Info

41

Alderton GK, et al. (2006) Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol 8, 725-33
16783362   Curated Info

42

Arnould S, et al. (2006) Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling. Mol Cancer Ther 5, 1602-9
16818520   Curated Info

43

Shiromizu T, et al. (2006) Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells 11, 477-85
16629900   Curated Info

44

Dodson GE, Tibbetts RS (2006) DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem 281, 1692-7
16293623   Curated Info

45

Zhang YW, et al. (2005) Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell 19, 607-18
16137618   Curated Info

46

Clarke CA, Clarke PR (2005) DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochem J 388, 705-12
15707391   Curated Info

47

Bhoumik A, et al. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell 18, 577-87
15916964   Curated Info

48

Lu X, Nannenga B, Donehower LA (2005) PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 19, 1162-74
15870257   Curated Info

49

Rocha S, et al. (2005) Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 24, 1157-69
15775976   Curated Info

50

Kurz EU, Douglas P, Lees-Miller SP (2004) Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. J Biol Chem 279, 53272-81
15489221   Curated Info

51

Yu X, Chen J (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24, 9478-86
15485915   Curated Info

52

Yan T, et al. (2004) CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. Mol Cancer Ther 3, 1147-57
15367709   Curated Info

53

Zhu W, Chen Y, Dutta A (2004) Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint. Mol Cell Biol 24, 7140-50
15282313   Curated Info

54

Fabbro M, et al. (2004) BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem 279, 31251-8
15159397   Curated Info

55

Cortez D, Glick G, Elledge SJ (2004) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A 101, 10078-83
15210935   Curated Info

56

Gatei M, et al. (2003) Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem 278, 14806-11
12588868   Curated Info

57

Zhao H, Piwnica-Worms H (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21, 4129-39
11390642   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.