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Site Group Page (References Reporting Low Throughput Detection Method)
 

Site Information
InsR (human) Y1185-p FGMTRDIyETDYYRK 1, 2, 5, 6, 8, 10, 11, 13, 14, 15, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 33
InsR iso2 (human) Y1173-p FGMTRDIyETDYYRK 18
InsR (mouse) Y1175-p FGMTRDIyETDYYRK 4, 7
InsR (rat) Y1186-p FGMTRDIyETDYYRK 3, 9, 12, 16, 17, 32, 34

References

1

Fafalios A, et al. (2011) A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nat Med 17, 1577-84
22081023   Curated Info

2

Nakachi I, et al. (2010) The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-Met inhibition. Mol Cancer Res 8, 1142-51
20647329   Curated Info

3

Muñoz MC, et al. (2009) TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. J Endocrinol 201, 185-97
19251743   Curated Info

4

Yoshizaki T, et al. (2007) Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation. Mol Cell Biol 27, 5172-83
17515613   Curated Info

5

Andreozzi F, et al. (2007) Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol 27, 2372-83
17242212   Curated Info

6

Nouaille S, et al. (2006) Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO Rep 7, 512-8
16582879   Curated Info

7

Fang CX, et al. (2006) Metallothionein antagonizes aging-induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt. Aging Cell 5, 177-85
16626396   Curated Info

8

Denley A, et al. (2006) Differential activation of insulin receptor isoforms by insulin-like growth factors is determined by the C domain. Endocrinology 147, 1029-36
16239300   Curated Info

9

Ma Y, et al. (2004) Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. Endocrinology 145, 5168-76
15297437   Curated Info

10

Holland W, et al. (2004) Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol 67, 2081-91
15135305   Curated Info

11

Andreozzi F, et al. (2004) Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells. Circ Res 94, 1211-8
15044323   Curated Info

12

Schliess F, et al. (2004) Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J Biol Chem 279, 21294-301
14985360   Curated Info

13

Hu J, et al. (2003) Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell 12, 1379-89
14690593   Curated Info

14

Li Y, et al. (2003) Morphine induces desensitization of insulin receptor signaling. Mol Cell Biol 23, 6255-66
12917346   Curated Info

15

Wick KR, et al. (2003) Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem 278, 8460-7
12493740   Curated Info

16

Hers I, et al. (2002) Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Biochem J 368, 875-84
12220227   Curated Info

17

Motley ED, et al. (2002) Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. Hypertension 39, 508-12
11882599   Curated Info

18

Tennagels N, et al. (2001) Identification of Ser(1275) and Ser(1309) as autophosphorylation sites of the human insulin receptor in intact cells. Biochem Biophys Res Commun 282, 387-93
11401470   Curated Info

19

Salmeen A, et al. (2000) Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell 6, 1401-12
11163213   Curated Info

20

Tennagels N, Bergschneider E, Al-Hasani H, Klein HW (2000) Autophosphorylation of the two C-terminal tyrosine residues Tyr1316 and Tyr1322 modulates the activity of the insulin receptor kinase in vitro. FEBS Lett 479, 67-71
10940390   Curated Info

21

Noelle V, Tennagels N, Klein HW (2000) A single substitution of the insulin receptor kinase inhibits serine autophosphorylation in vitro: evidence for an interaction between the C-terminus and the activation loop. Biochemistry 39, 7170-7
10852715   Curated Info

22

Schmid E, Hotz-Wagenblatt A, Hacj V, Dröge W (1999) Phosphorylation of the insulin receptor kinase by phosphocreatine in combination with hydrogen peroxide: the structural basis of redox priming. FASEB J 13, 1491-500
10463939   Curated Info

23

Sawka-Verhelle D, et al. (1997) Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor. J Biol Chem 272, 16414-20
9195949   Curated Info

24

Bandyopadhyay D, et al. (1997) Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. J Biol Chem 272, 1639-45
8999839   Curated Info

25

Al-Hasani H, et al. (1997) Identification of Ser-1275 and Ser-1309 as autophosphorylation sites of the insulin receptor. FEBS Lett 400, 65-70
9000514   Curated Info

26

Smith JE, Sheng ZF, Kallen RG (1994) Effects of tyrosine-->phenylalanine mutations on auto- and trans-phosphorylation reactions catalyzed by the insulin receptor beta-subunit cytoplasmic domain. DNA Cell Biol 13, 593-604
8024702   Curated Info

27

Dickens M, Tavaré JM (1992) Analysis of the order of autophosphorylation of human insulin receptor tyrosines 1158, 1162 and 1163. Biochem Biophys Res Commun 186, 244-50
1321605   Curated Info

28

Murakami MS, Rosen OM (1991) The role of insulin receptor autophosphorylation in signal transduction. J Biol Chem 266, 22653-60
1658004   Curated Info

29

Tappia PS, Sharma RP, Sale GJ (1991) Dephosphorylation of autophosphorylated insulin and epidermal-growth-factor receptors by two major subtypes of protein-tyrosine-phosphatase from human placenta. Biochem J 278 ( Pt 1), 69-74
1715686   Curated Info

30

Myers MG, Backer JM, Siddle K, White MF (1991) The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus. J Biol Chem 266, 10616-23
1645354   Curated Info

31

King MJ, Sale GJ (1990) Dephosphorylation of insulin-receptor autophosphorylation sites by particulate and soluble phosphotyrosyl-protein phosphatases. Biochem J 266, 251-9
1689998   Curated Info

32

Kruszynska YT, Halban PA, Kahn CR, White MF (1990) Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats. Diabetologia 33, 77-83
2158467   Curated Info

33

Tavaré JM, Denton RM (1988) Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping. Biochem J 252, 607-15
3166375   Curated Info

34

White MF, Shoelson SE, Keutmann H, Kahn CR (1988) A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem 263, 2969-80
2449432   Curated Info

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