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Site Group Page (References Reporting Low Throughput Detection Method)
 

Site Information
Syk (human) Y526-p LRADENYyKAQTHGK 1, 2, 3, 5, 6, 9, 10, 12, 15, 16, 18, 20
Syk iso2 (human) Y503-p LRADENYyKAQTHGK
Syk (mouse) Y520-p LRADENYyKAQTHGK 4, 6, 7, 11, 13, 14, 17, 19
Syk (rat) Y520-p LRADENYyKAQTHGK 7, 8

References

1

Sangkhae V, et al. (2014) Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. Exp Hematol 42, 477-86.e4
24607955   Curated Info

2

Uotila LM, Aatonen M, Gahmberg CG (2013) Integrin CD11c/CD18 α-Chain Phosphorylation Is Functionally Important. J Biol Chem 288, 33494-9
24129562   Curated Info

3

Chang MY, et al. (2012) PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation. PLoS One 7, e40999
22848421   Curated Info

4

Chaturvedi A, et al. (2011) Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments. Nat Immunol 12, 1119-26
21964606   Curated Info

5

Pighi C, et al. (2011) Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling. Cell Oncol (Dordr) 34, 141-53
21394647   Curated Info

6

Chen X, et al. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem 285, 31268-76
20670933   Curated Info

7

Sanderson MP, et al. (2010) Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation. Mol Immunol 48, 171-8
20828828   Curated Info

8

de Castro RO, et al. (2010) Tyrosines in the carboxyl terminus regulate syk kinase activity and function. J Biol Chem 285, 26674-84
20554527   Curated Info

9

Lee SH, et al. (2010) Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2. J Immunol 185, 917-28
20543098   Curated Info

10

Tsang E, et al. (2008) Molecular mechanism of the Syk activation switch. J Biol Chem 283, 32650-9
18818202   Curated Info

11

Bezman NA, et al. (2008) Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exp Med 205, 1775-88
18663126   Curated Info

12

Bijli KM, Fazal F, Minhajuddin M, Rahman A (2008) Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. J Biol Chem 283, 14674-84
18362147   Curated Info

13

Xu JW, et al. (2007) C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 21, 564-73
17095576   Curated Info

14

Ueki Y, et al. (2007) Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell 128, 71-83
17218256   Curated Info

15

Dangelmaier CA, et al. (2005) Rapid ubiquitination of Syk following GPVI activation in platelets. Blood 105, 3918-24
15701717   Curated Info

16

Suzuki-Inoue K, et al. (2004) Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites. Biochem J 378, 1023-9
14656219   Curated Info

17

Vines CM, et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15, 507-19
11672534   Curated Info

18

Hitomi T, et al. (2001) Requirement of Syk-phospholipase C-gamma2 pathway for phorbol ester-induced phospholipase D activation in DT40 cells. Genes Cells 6, 475-85
11380624   Curated Info

19

Keshvara LM, et al. (1998) Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol 161, 5276-83
9820500   Curated Info

20

Law CL, Chandran KA, Sidorenko SP, Clark EA (1996) Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol 16, 1305-15
8657103   Curated Info

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