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Site Group Page (References Reporting Low Throughput Detection Method)
 

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Smad2 (human) S467-p SVRCSSMs_______ 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 25, 27, 28, 29, 30, 31
Smad2 (mouse) S467-p SVRCSSMs_______ 1, 2, 9, 14, 15, 23, 26
Smad2 (rat) S467-p SVRCSSMs_______ 14

References

1

de Almeida CJ, Jasmin JF, Del Galdo F, Lisanti MP (2013) Genetic ablation of caveolin-2 sensitizes mice to bleomycin-induced injury. Cell Cycle 12, 2248-54
24067367   Curated Info

2

Utreras E, et al. (2013) TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain 9, 24
23668392   Curated Info

3

Williams G, et al. (2013) Transcriptional basis for the inhibition of neural stem cell proliferation and migration by the TGFβ-family member GDF11. PLoS One 8, e78478
24244313   Curated Info

4

Manser C, et al. (2012) Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo. Oncogene 31, 2773-82
21996745   Curated Info

5

Yan X, et al. (2012) p21-activated Kinase 2 (PAK2) Inhibits TGF-β Signaling in Madin-Darby Canine Kidney (MDCK) Epithelial Cells by Interfering with the Receptor-Smad Interaction. J Biol Chem 287, 13705-12
22393057   Curated Info

6

Singh AM, et al. (2012) Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell 10, 312-26
22385658   Curated Info

7

Cherukuri P, et al. (2012) Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ. PLoS One 7, e50066
23166821   Curated Info

8

Fu G, Peng C (2011) Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells. Oncogene 30, 3953-66
21532621   Curated Info

9

Knauf JA, et al. (2011) Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling. Oncogene 30, 3153-62
21383698   Curated Info

10

Frederick MJ, et al. (2011) Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. Am J Pathol 178, 548-71
21281788   Curated Info

11

Wang W, et al. (2009) Structural and mechanistic insights into Mps1 kinase activation. J Cell Mol Med 13, 1679-94
19120698   Curated Info

12

Li F, Pham JD, Anderson MO, Youngren JF (2009) Nordihydroguaiaretic acid inhibits transforming growth factor beta type 1 receptor activity and downstream signaling. Eur J Pharmacol 616, 31-7
19540220   Curated Info

13

Zhao S, et al. (2008) Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res 68, 4221-8
18519681   Curated Info

14

Samarakoon R, Higgins SP, Higgins CE, Higgins PJ (2008) TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling. J Mol Cell Cardiol 44, 527-38
18255094   Curated Info

15

Takatori A, et al. (2008) Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development 135, 23-32
18032450   Curated Info

16

Milyavsky M, et al. (2007) Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. Cancer Cell 11, 133-46
17292825   Curated Info

17

Chen J, Chen JK, Neilson EG, Harris RC (2006) Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy. J Am Soc Nephrol 17, 1615-23
16641152   Curated Info

18

Ho J, et al. (2005) The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction. EMBO J 24, 3247-58
16121194   Curated Info

19

Wang SE, et al. (2005) Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function. Mol Cell Biol 25, 4703-15
15899872   Curated Info

20

Loeys BL, et al. (2005) A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 37, 275-81
15731757   Curated Info

21

Kamaraju AK, Roberts AB (2005) Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo. J Biol Chem 280, 1024-36
15520018   Curated Info

22

Ottesen JJ, Huse M, Sekedat MD, Muir TW (2004) Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase. Biochemistry 43, 5698-706
15134444   Curated Info

23

Haller D, et al. (2003) Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. J Biol Chem 278, 23851-60
12672795   Curated Info

24

Bourguignon LY, Singleton PA, Zhu H, Zhou B (2002) Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem 277, 39703-12
12145287   Curated Info

25

Abdel-Wahab N, Wicks SJ, Mason RM, Chantry A (2002) Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240. Biochem J 362, 643-9
11879191   Curated Info

26

Bakin AV, et al. (2000) Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275, 36803-10
10969078   Curated Info

27

Funaba M, Mathews LS (2000) Identification and characterization of constitutively active Smad2 mutants: evaluation of formation of Smad complex and subcellular distribution. Mol Endocrinol 14, 1583-91
11043574   Curated Info

28

Souchelnytskyi S, et al. (1997) Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J Biol Chem 272, 28107-15
9346966   Curated Info

29

Abdollah S, et al. (1997) TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J Biol Chem 272, 27678-85
9346908   Curated Info

30

Kretzschmar M, et al. (1997) The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev 11, 984-95
9136927   Curated Info

31

Macías-Silva M, et al. (1996) MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-24
8980228   Curated Info

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