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Chk1 (human) S317-p ENVkYsssQPEPRTG Links 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 45, 46, 47, 48, 49, 50, 52, 53, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
Chk1 (mouse) S317-p ETVKFsSsQPEPRTG Links 44, 51, 54, 55



Ortega-Atienza S, Rubis B, McCarthy C, Zhitkovich A (2016) Formaldehyde Is a Potent Proteotoxic Stressor Causing Rapid Heat Shock Factor Protein 1 Activation and Lys48-Linked Polyubiquitination of Proteins. Am J Pathol
27639166   Curated Info


Lima M, et al. (2016) Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair. Oncotarget 7, 25885-901
27029031   Curated Info


Peng C, et al. (2016) The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling. Cancer Res 76, 2340-53
26960975   Curated Info


Cea M, et al. (2016) Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood 127, 1138-50
26675349   Curated Info


Matsunuma R, et al. (2016) UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation. Mol Cell Biol 36, 394-406
26572825   Curated Info


Moudry P, et al. (2016) TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J Cell Biol 212, 281-8
26811421   Curated Info


Beyaert M, Starczewska E, Van Den Neste E, Bontemps F (2016) A crucial role for ATR in the regulation of deoxycytidine kinase activity. Biochem Pharmacol 100, 40-50
26620371   Curated Info


Langlands H, Blain PG, Jowsey PA (2016) Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage. PLoS One 11, e0155056
27176072   Curated Info


Higgs MR, et al. (2015) BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. Mol Cell 59, 462-77
26166705   Curated Info


Hao J, et al. (2015) And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. EMBO J 34, 2096-110
26082189   Curated Info


Chiker S, et al. (2015) Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients. Cell Cycle 14, 3066-78
26237679   Curated Info


Saini P, Li Y, Dobbelstein M (2015) Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress. Oncotarget 6, 13072-87
25965828   Curated Info


Wang WT, Catto JW, Meuth M (2015) Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors. Oncogene 34, 2887-96
25043304   Curated Info


Chang FT, et al. (2015) CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. Nucleic Acids Res 43, 2603-14
25690891   Curated Info


Martín Y, et al. (2015) USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination. Oncogene 34, 1058-63
24632611   Curated Info


Osorio-Zambrano WF, Davey S (2015) Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling. PLoS One 10, e0144434
26658951   Curated Info


Hirokawa T, et al. (2014) CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint. Cancer Res 74, 3880-9
24876101   Curated Info


Kubota S, et al. (2014) Activation of the Prereplication Complex Is Blocked by Mimosine through Reactive Oxygen Species-activated Ataxia Telangiectasia Mutated (ATM) Protein without DNA Damage. J Biol Chem 289, 5730-46
24421316   Curated Info


Penicud K, Behrens A (2014) DMAP1 is an essential regulator of ATM activity and function. Oncogene 33, 525-31
23318425   Curated Info


Luzwick JW, Nam EA, Zhao R, Cortez D (2014) Mutation of Serine 1333 in the ATR HEAT Repeats Creates a Hyperactive Kinase. PLoS One 9, e99397
24901225   Curated Info


FitzGerald J, et al. (2014) A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response. PLoS One 9, e98891
24902048   Curated Info


Yamada M, et al. (2013) ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. Genes Dev 27, 2459-72
24240236   Curated Info


Couch FB, et al. (2013) ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Genes Dev 27, 1610-23
23873943   Curated Info


Cheng YC, Lin TY, Shieh SY (2013) Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1. Proc Natl Acad Sci U S A 110, 5993-8
23533280   Curated Info


Chilà R, et al. (2013) Chk1-Mad2 interaction: A crosslink between the DNA damage checkpoint and the mitotic spindle checkpoint. Cell Cycle 12, 1083-90
23454898   Curated Info


Sokol AM, Cruet-Hennequart S, Pasero P, Carty MP (2013) DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells. Sci Rep 3, 3277
24253929   Curated Info


Sato K, et al. (2012) A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair. Curr Biol 22, 1659-66
22863316   Curated Info


Lee AY, et al. (2012) Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. J Biol Chem 287, 2531-43
22123827   Curated Info


Prendergast ÁM, et al. (2011) Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation. Cell Cycle 10, 3768-77
22037398   Curated Info


Nam EA, Zhao R, Cortez D (2011) Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. J Biol Chem 286, 37320-7
21908846   Curated Info


Lossaint G, et al. (2011) Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. Oncogene 30, 4261-74
21532626   Curated Info


Xu N, Libertini S, Zhang Y, Gillespie DA (2011) Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency. Biochem Biophys Res Commun 413, 465-70
21907702   Curated Info


Carlessi L, Buscemi G, Fontanella E, Delia D (2010) A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage. Biochim Biophys Acta 1803, 1213-23
20599567   Curated Info


Kasahara K, et al. (2010) 14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage. EMBO J 29, 2802-12
20639859   Curated Info


Yan Y, et al. (2010) Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene 29, 4317-29
20498628   Curated Info


Greer Card DA, Sierant ML, Davey S (2010) Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition. J Biol Chem 285, 15653-61
20305300   Curated Info


Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG (2010) Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell 140, 349-59
20116089   Curated Info


Freeman AK, Dapic V, Monteiro AN (2010) Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage. Cell Cycle 9, 736-47
20160490   Curated Info


Zhong D, et al. (2009) The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R. J Biol Chem 284, 23225-33
19574224   Curated Info


Berglund FM, Clarke PR (2009) hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks. Biochem Biophys Res Commun 381, 59-64
19351595   Curated Info


Wilsker D, Petermann E, Helleday T, Bunz F (2008) Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci U S A 105, 20752-7
19091954   Curated Info


Ikegami Y, et al. (2008) Chk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication and damage checkpoint stimulation. Biochem Biophys Res Commun 377, 1227-31
18983824   Curated Info


Collis SJ, et al. (2008) FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell 32, 313-24
18995830   Curated Info


Hitomi M, Yang K, Stacey AW, Stacey DW (2008) Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression. Mol Cell Biol 28, 5478-93
18606783   Curated Info


Yan Y, et al. (2008) Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. Cancer Res 68, 5113-21
18593910   Curated Info


Petermann E, Helleday T, Caldecott KW (2008) Claspin promotes normal replication fork rates in human cells. Mol Biol Cell 19, 2373-8
18353973   Curated Info


Campregher C, Luciani MG, Gasche C (2008) Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. Gut 57, 780-7
18272544   Curated Info


Sidi S, et al. (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133, 864-77
18510930   Curated Info


Richard DJ, et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453, 677-81
18449195   Curated Info


Cruet-Hennequart S, et al. (2008) Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin. DNA Repair (Amst) 7, 582-96
18289945   Curated Info


Yang YG, Lindahl T, Barnes DE (2007) Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131, 873-86
18045533   Curated Info


Olson E, et al. (2007) The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem 282, 22939-52
17526493   Curated Info


Yan Y, Black CP, Cowan KH (2007) Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene 26, 4689-98
17297454   Curated Info


Difilippantonio S, et al. (2007) Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med 204, 1003-11
17485521   Curated Info


Niida H, et al. (2007) Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol 27, 2572-81
17242188   Curated Info


Carlessi L, et al. (2007) Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2. Mol Cancer Ther 6, 935-44
17363488   Curated Info


Stiff T, et al. (2006) ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 25, 5775-82
17124492   Curated Info


Chini CC, Chen J (2006) Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem 281, 33276-82
16963448   Curated Info


Leung-Pineda V, Ryan CE, Piwnica-Worms H (2006) Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol 26, 7529-38
17015476   Curated Info


Alderton GK, et al. (2006) Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol 8, 725-33
16783362   Curated Info


Arnould S, et al. (2006) Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling. Mol Cancer Ther 5, 1602-9
16818520   Curated Info


Shiromizu T, et al. (2006) Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells 11, 477-85
16629900   Curated Info


Dodson GE, Tibbetts RS (2006) DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem 281, 1692-7
16293623   Curated Info


Zhang YW, et al. (2005) Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Mol Cell 19, 607-18
16137618   Curated Info


Clarke CA, Clarke PR (2005) DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. Biochem J 388, 705-12
15707391   Curated Info


Bhoumik A, et al. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell 18, 577-87
15916964   Curated Info


Lu X, Nannenga B, Donehower LA (2005) PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 19, 1162-74
15870257   Curated Info


Rocha S, et al. (2005) Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 24, 1157-69
15775976   Curated Info


Kurz EU, Douglas P, Lees-Miller SP (2004) Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. J Biol Chem 279, 53272-81
15489221   Curated Info


Yu X, Chen J (2004) DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24, 9478-86
15485915   Curated Info


Yan T, et al. (2004) CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. Mol Cancer Ther 3, 1147-57
15367709   Curated Info


Zhu W, Chen Y, Dutta A (2004) Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint. Mol Cell Biol 24, 7140-50
15282313   Curated Info


Fabbro M, et al. (2004) BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem 279, 31251-8
15159397   Curated Info


Cortez D, Glick G, Elledge SJ (2004) Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A 101, 10078-83
15210935   Curated Info


Gatei M, et al. (2003) Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J Biol Chem 278, 14806-11
12588868   Curated Info


Zhao H, Piwnica-Worms H (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol 21, 4129-39
11390642   Curated Info

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