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Site Group Page (LTP records: Sites observed with LTP technologies)
 

Site Information
Syk (human) Y526-p LRADENyyKAQtHGK Links 2, 3, 7, 8, 9, 11, 12, 15, 16, 18, 21, 22, 24, 26
Syk (mouse) Y520-p LRADENyyKAQTHGK Links 1, 4, 5, 6, 10, 12, 13, 17, 19, 20, 23, 25
Syk (rat) Y520-p LRADENyyKAQTHGK Links 13, 14

Records

1

Reppschläger K, et al. (2016) TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem 291, 22427-22441
27609517   Curated Info

2

Booth L, et al. (2016) Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo. Oncotarget
27259258   Curated Info

3

Lin L, et al. (2016) Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3. Oncotarget 7, 9844-58
26848618   Curated Info

4

Abdala-Valencia H, et al. (2015) Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation. J Immunol 195, 1377-87
26136426   Curated Info

5

Yu Y, et al. (2015) Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell 28, 82-96
26096845   Curated Info

6

Baldwin KT, Carbajal KS, Segal BM, Giger RJ (2015) Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration. Proc Natl Acad Sci U S A 112, 2581-6
25675510   Curated Info

7

Sangkhae V, et al. (2014) Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. Exp Hematol 42, 477-86.e4
24607955   Curated Info

8

Uotila LM, Aatonen M, Gahmberg CG (2013) Integrin CD11c/CD18 α-Chain Phosphorylation Is Functionally Important. J Biol Chem 288, 33494-9
24129562   Curated Info

9

Chang MY, et al. (2012) PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation. PLoS One 7, e40999
22848421   Curated Info

10

Chaturvedi A, et al. (2011) Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments. Nat Immunol 12, 1119-26
21964606   Curated Info

11

Pighi C, et al. (2011) Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling. Cell Oncol (Dordr) 34, 141-53
21394647   Curated Info

12

Chen X, et al. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem 285, 31268-76
20670933   Curated Info

13

Sanderson MP, et al. (2010) Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation. Mol Immunol 48, 171-8
20828828   Curated Info

14

de Castro RO, et al. (2010) Tyrosines in the carboxyl terminus regulate syk kinase activity and function. J Biol Chem 285, 26674-84
20554527   Curated Info

15

Lee SH, et al. (2010) Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2. J Immunol 185, 917-28
20543098   Curated Info

16

Tsang E, et al. (2008) Molecular mechanism of the Syk activation switch. J Biol Chem 283, 32650-9
18818202   Curated Info

17

Bezman NA, et al. (2008) Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exp Med 205, 1775-88
18663126   Curated Info

18

Bijli KM, Fazal F, Minhajuddin M, Rahman A (2008) Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. J Biol Chem 283, 14674-84
18362147   Curated Info

19

Xu JW, et al. (2007) C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 21, 564-73
17095576   Curated Info

20

Ueki Y, et al. (2007) Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell 128, 71-83
17218256   Curated Info

21

Dangelmaier CA, et al. (2005) Rapid ubiquitination of Syk following GPVI activation in platelets. Blood 105, 3918-24
15701717   Curated Info

22

Suzuki-Inoue K, et al. (2004) Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites. Biochem J 378, 1023-9
14656219   Curated Info

23

Vines CM, et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15, 507-19
11672534   Curated Info

24

Hitomi T, et al. (2001) Requirement of Syk-phospholipase C-gamma2 pathway for phorbol ester-induced phospholipase D activation in DT40 cells. Genes Cells 6, 475-85
11380624   Curated Info

25

Keshvara LM, et al. (1998) Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol 161, 5276-83
9820500   Curated Info

26

Law CL, Chandran KA, Sidorenko SP, Clark EA (1996) Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol 16, 1305-15
8657103   Curated Info

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