Site Group Page (LTP records: those reporting < 100 non-redundant sites)
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Site Group Page (LTP records: those reporting < 100 non-redundant sites)
 

Site Information
Syk (human) Y526-p LRADENYyKAQTHGK Links 1, 2, 6, 7, 8, 10, 11, 14, 15, 17, 20, 21, 23, 25
Syk (mouse) Y520-p LRADENYyKAQTHGK Links 3, 4, 5, 9, 11, 12, 16, 18, 19, 22, 24
Syk (rat) Y520-p LRADENYyKAQTHGK Links 12, 13

Records

1

Booth L, et al. (2016) Multi-kinase inhibitors interact with sildenafil and ERBB1/2/4 inhibitors to kill tumor cells in vitro and in vivo. Oncotarget
27259258   Curated Info

2

Lin L, et al. (2016) Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3. Oncotarget 7, 9844-58
26848618   Curated Info

3

Abdala-Valencia H, et al. (2015) Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation. J Immunol 195, 1377-87
26136426   Curated Info

4

Yu Y, et al. (2015) Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell 28, 82-96
26096845   Curated Info

5

Baldwin KT, Carbajal KS, Segal BM, Giger RJ (2015) Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration. Proc Natl Acad Sci U S A 112, 2581-6
25675510   Curated Info

6

Sangkhae V, et al. (2014) Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. Exp Hematol 42, 477-86.e4
24607955   Curated Info

7

Uotila LM, Aatonen M, Gahmberg CG (2013) Integrin CD11c/CD18 α-Chain Phosphorylation Is Functionally Important. J Biol Chem 288, 33494-9
24129562   Curated Info

8

Chang MY, et al. (2012) PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation. PLoS One 7, e40999
22848421   Curated Info

9

Chaturvedi A, et al. (2011) Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments. Nat Immunol 12, 1119-26
21964606   Curated Info

10

Pighi C, et al. (2011) Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling. Cell Oncol (Dordr) 34, 141-53
21394647   Curated Info

11

Chen X, et al. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem 285, 31268-76
20670933   Curated Info

12

Sanderson MP, et al. (2010) Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation. Mol Immunol 48, 171-8
20828828   Curated Info

13

de Castro RO, et al. (2010) Tyrosines in the carboxyl terminus regulate syk kinase activity and function. J Biol Chem 285, 26674-84
20554527   Curated Info

14

Lee SH, et al. (2010) Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2. J Immunol 185, 917-28
20543098   Curated Info

15

Tsang E, et al. (2008) Molecular mechanism of the Syk activation switch. J Biol Chem 283, 32650-9
18818202   Curated Info

16

Bezman NA, et al. (2008) Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exp Med 205, 1775-88
18663126   Curated Info

17

Bijli KM, Fazal F, Minhajuddin M, Rahman A (2008) Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. J Biol Chem 283, 14674-84
18362147   Curated Info

18

Xu JW, et al. (2007) C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 21, 564-73
17095576   Curated Info

19

Ueki Y, et al. (2007) Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell 128, 71-83
17218256   Curated Info

20

Dangelmaier CA, et al. (2005) Rapid ubiquitination of Syk following GPVI activation in platelets. Blood 105, 3918-24
15701717   Curated Info

21

Suzuki-Inoue K, et al. (2004) Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites. Biochem J 378, 1023-9
14656219   Curated Info

22

Vines CM, et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15, 507-19
11672534   Curated Info

23

Hitomi T, et al. (2001) Requirement of Syk-phospholipase C-gamma2 pathway for phorbol ester-induced phospholipase D activation in DT40 cells. Genes Cells 6, 475-85
11380624   Curated Info

24

Keshvara LM, et al. (1998) Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol 161, 5276-83
9820500   Curated Info

25

Law CL, Chandran KA, Sidorenko SP, Clark EA (1996) Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol 16, 1305-15
8657103   Curated Info

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.