Tyr1440

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Phosphorylation Site Page:

Tyr1440 - ITGB4 iso2 (human)

Site Information

STTLPRDySTLTSVS SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: ITGB4 (human): Y1510, ITGB4 (rat): Y1441, ITGB4 iso2 (mouse): Y1441, ITGB4 iso3 (human): Y1440, ITGB4 (mouse): Y1506, ITGB4 iso3 (mouse): Y1441

Blast this site against: NCBI SwissProt PDB

Available spectra: 2 CST

In vivo Characterization

Methods used to characterize site in vivo:	immunoprecipitation (1), mass spectrometry (2, 3, 4, 5, 6), mutation of modification site (1, 7), phospho-antibody (1, 7), western blotting (1, 7)
Disease tissue studied:	bladder cancer (7), breast cancer (1), gastric cancer (5), gastric carcinoma (5), lung cancer (5), non-small cell lung cancer (5), non-small cell lung adenocarcinoma (5), pancreatic cancer (6)
Relevant cell line - cell type - tissue:	293T (epithelial) (7), 804G (epithelial) (7), BxPC-3 (pancreatic) (6), HaCaT (keratinocyte) (7), HCC827 (pulmonary) (5), HUVEC (endothelial) (7), MDA-MB231 (breast cell) (1), MDA-MB435 (breast cell) (1), MKN-45 (gastric) (2, 3, 5), NCI-H1666 (pulmonary) (5), NCI-H2228 (pulmonary) (4), NCI-H3255 (pulmonary) (5)

Controlled by

Treatments:

vanadate (7)

Downstream Regulation

Effects of modification on ITGB4 iso2:	activation (1), molecular association, regulation (7)
Effects of modification on biological processes:	cell adhesion, altered (7), cell motility, altered (1)
Induce interaction with:	Shc1 (human) (7)

	References

1	Yang X, Dutta U, Shaw LM (2010) SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion. Mol Cell Biol 30, 5306-17 20855525 Curated Info
2	(2008) CST Curation Set: 5770; Year: 2008; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: Su11274; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	(2008) CST Curation Set: 5771; Year: 2008; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: Su11274; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	(2008) CST Curation Set: 5327; Year: 2008; Biosample: NCI-H2228; Disease: non-small cell lung adenocarcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	Guo A, et al. (2008) Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A 105, 692-7 18180459 Curated Info
6	(2004) CST Curation Set: 411; Year: 2004; SILAC: Y; Biosample1/Treatment/Isotope: BxPC-3/EGF & Iressa/L; Biosample2/Treatment/Isotope: BxPC-3/EGF/H; Disease: pancreatic carcinoma; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	Dans M, et al. (2001) Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem 276, 1494-502 11044453 Curated Info

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