Tyr1422
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Phosphorylation Site Page:
Tyr1422 - ITGB4 iso2 (human)

Site Information
SSTLTRDyNSLTRSE    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: ITGB4 iso3 (mouse): Y1423, ITGB4 (mouse): Y1488, ITGB4 iso3 (human): Y1422, ITGB4 (human): Y1492, ITGB4 iso2 (mouse): Y1423, ITGB4 (rat): Y1423
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1), mutation of modification site (2), phospho-antibody (2), western blotting (2)
Disease tissue studied: bladder cancer (2)
Relevant cell line - cell type - tissue: 293T (epithelial) (2), 804G (epithelial) (2), HaCaT (keratinocyte) (2), HUVEC (endothelial) (2), MKN-45 (gastric) (1)


Downstream Regulation
Effects of modification on ITGB4 iso2: molecular association, regulation (2)
Effects of modification on biological processes: cell adhesion, altered (2)
Induce interaction with: Shc1 (human) (2)


References

1

(2008) CST Curation Set: 5770; Year: 2008; Biosample/Treatment: cell line, MKN-45/Su11274; Disease: gastric carcinoma; SILAC: -; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Dans M, et al. (2001) Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem 276, 1494-502
11044453   Curated Info

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