Ser599
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Phosphorylation Site Page:
Ser599 - JMJD1B (mouse)

Site Information
FEAVKRFsLDERSLA    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: JMJD1B (human): S798, JMJD1B iso3 (mouse): S799
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471053

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1, 2, 3, 4)
Disease tissue studied: leukemia (1), acute myelogenous leukemia (1), melanoma skin cancer (4)
Relevant cell line - cell type - tissue: 32Dcl3 (myeloid) (3), 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ~aa 525-695 ETILLNS...IFEYCC)] (3), blood (1), macrophage-bone marrow (2), macrophage-bone marrow [MKP-1 (mouse), homozygous knockout] (2), skin [mGluR1 (mouse), transgenic, TG mutant mice] (4)

Controlled by
Treatments: LPS (2)



References

1

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

2

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

3

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

4

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

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