Ser33
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Phosphorylation Site Page:
Ser33 - CTNNB1 (mouse)

Site Information
QQQSYLDsGIHSGAT    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CTNNB1 (human): S33, CTNNB1 (rat): S33
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (14), mutation of modification site (5, 13, 14), phospho-antibody (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11), western blotting (1, 3, 4, 5, 6, 7, 8, 9, 10, 14)
Disease tissue studied: neuroblastoma (14)
Relevant cell line - cell type - tissue: 'brain, striatum' (11), 'neuron, cortical'-brain (3), 'neuron, hippocampal'-brain (3), 293 (epithelial) (5), 293T (epithelial) (4), brain (6), brain [CDK5R1 (mouse)] (6), E14tg2a ('stem, embryonic') (10), epithelial [PIK3R1 (mouse), homozygous knockout] (2), intestine [CK1A (mouse), homozygous knockout] (1), L cells (fibroblast) (8, 9), MEF (fibroblast) (13), MEF (fibroblast) [JNK1 (mouse), transfection] (5), Neuro-2A (neuron) (14), uterus (7)

Controlled by
Regulatory protein: CDK5R1 (mouse) (6), CK1A (mouse) (1), DISC1 (human) (3), DISC1 (mouse) (3), Huntingtin (mouse) (11), PIK3R1 (mouse) (2), ZBED3 (mouse) (4)
Putative upstream kinases: GSK3B (human) (4, 14)
Kinases, in vitro: GSK3B (mouse) (12)
Treatments: LIF (10), LLnL (14), LY294002 (10), MG132 (8), QLT0267 (9), siRNA (3), Wnt3a (9)

Downstream Regulation
Effects of modification on CTNNB1: activity, induced (13), protein degradation (14), ubiquitination (14)
Effects of modification on biological processes: transcription, altered (13)


References

1

Elyada E, et al. (2011) CKI╬▒ ablation highlights a critical role for p53 in invasiveness control. Nature 470, 409-13
21331045   Curated Info

2

Lee G, et al. (2010) Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-81, 881.e1-9
20580720   Curated Info

3

Mao Y, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136, 1017-31
19303846   Curated Info

4

Chen T, et al. (2009) Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/{beta}-Catenin Signaling. J Biol Chem 284, 6683-9
19141611   Curated Info

5

Hu D, et al. (2008) c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 29, 2317-24
18952597   Curated Info

6

Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-32
18322105   Curated Info

7

Herington JL, Bi J, Martin JD, Bany BM (2007) Beta-catenin (CTNNB1) in the mouse uterus during decidualization and the potential role of two pathways in regulating its degradation. J Histochem Cytochem 55, 963-74
17533218   Curated Info

8

Abe K, Takeichi M (2007) NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron 53, 387-97
17270735   Curated Info

9

Oloumi A, Syam S, Dedhar S (2006) Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 25, 7747-57
16799642   Curated Info

10

Paling NR, Wheadon H, Bone HK, Welham MJ (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279, 48063-70
15328362   Curated Info

11

Gines S, et al. (2003) Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells. J Biol Chem 278, 50514-22
14522959   Curated Info

12

Sakanaka C (2002) Phosphorylation and regulation of beta-catenin by casein kinase I epsilon. J Biochem (Tokyo) 132, 697-703
12417018   Curated Info

13

Aoki M, et al. (2002) Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes. Oncogene 21, 6983-91
12370820   Curated Info

14

Aberle H, et al. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-804
9233789   Curated Info

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