Tyr222
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Phosphorylation Site Page:
Tyr222 - CRK (chicken)

Site Information
GGPEPGPyAQPSINT    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CRK (human): Y221, CRK (rat): Y221, CRK (mouse): Y221, CRK iso3 (mouse): , CRK iso2 (human):
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mutation of modification site (1, 3), phospho-antibody (1, 3), western blotting (1, 3)
Disease tissue studied: adrenal cancer (3), pheochromocytoma (3)
Relevant cell line - cell type - tissue: 293T (epithelial) (1, 3), MEF (fibroblast) (3), PC-12 (chromaffin) (3)

Controlled by
Putative upstream kinases: Abl (human) (3)
Kinases, in vitro: Abl (human) (3), Arg (human) (2)
Treatments: NGF (3)

Downstream Regulation
Effects of modification on CRK: molecular association, regulation (1, 3), protein conformation (1)
Effects of modification on biological processes: cell adhesion, altered (3), cell differentiation, altered (3)
Inhibit interaction with: Abl (human) (1), Abl iso2 (human) (3), PXN (chicken) (3)


References

1

Sarkar P, et al. (2007) Proline cis-trans isomerization controls autoinhibition of a signaling protein. Mol Cell 25, 413-26
17289588   Curated Info

2

Hu H, Bliss JM, Wang Y, Colicelli J (2005) RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol 15, 815-23
15886098   Curated Info

3

Escalante M, et al. (2000) Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. J Biol Chem 275, 24787-97
10825157   Curated Info

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