Tyr222

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Phosphorylation Site Page:

Site Information

GGPEPGPyAQPSINT SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: Crk (human): Y221, Crk (rat): Y221, Crk (mouse): Y221, Crk iso2 (human): ‑

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mutation of modification site (1, 3), phospho-antibody (1, 3), western blotting (1, 3)
Disease tissue studied:	adrenal cancer (3), pheochromocytoma (3)
Relevant cell line - cell type - tissue:	293T (epithelial) (1, 3), MEF (fibroblast) (3), PC-12 (chromaffin) (3)

Controlled by

Downstream Regulation

Effects of modification on Crk:	molecular association, regulation (1, 3), protein conformation (1)
Effects of modification on biological processes:	cell adhesion, altered (3), cell differentiation, altered (3)
Inhibit interaction with:	Abl (human) (1), Abl iso2 (human) (3), PXN (chicken) (3)

	References

1	Sarkar P, et al. (2007) Proline cis-trans isomerization controls autoinhibition of a signaling protein. Mol Cell 25, 413-26 17289588 Curated Info
2	Hu H, Bliss JM, Wang Y, Colicelli J (2005) RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol 15, 815-23 15886098 Curated Info
3	Escalante M, et al. (2000) Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. J Biol Chem 275, 24787-97 10825157 Curated Info

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