Ser290
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Phosphorylation Site Page:
Ser290 - CREM iso3 (mouse)

Site Information
ASPGSLHsPQQLAEE    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CREM (human): S293, CREM (mouse): S178, CREM iso8 (human): S53, CREM iso3 (human): S281, CREM iso2 (human): S169, CREM iso2 (mouse): S178
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (1, 2), mutation of modification site (1), phosphoamino acid analysis (1, 2), phosphopeptide mapping (1, 2)
Relevant cell line - cell type - tissue: COS (fibroblast) (1, 2)

Controlled by
Putative upstream kinases: CDK1 (mouse) (1)
Kinases, in vitro: CDK1 (mouse) (1, 2)

Downstream Regulation
Effects of modification on CREM iso3: activity, inhibited (1)
Effects of modification on biological processes: transcription, altered (1)


References

1

de Groot RP, Derua R, Goris J, Sassone-Corsi P (1993) Phosphorylation and negative regulation of the transcriptional activator CREM by p34cdc2. Mol Endocrinol 7, 1495-50
8114763   Curated Info

2

de Groot RP, et al. (1993) Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12, 3903-11
8404858   Curated Info

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