Ser290

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Phosphorylation Site Page:

Site Information

ASPGSLHsPQQLAEE SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: CREM (human): S293, CREM (mouse): S178, CREM iso3 (human): S281, CREM iso2 (human): S169, CREM iso2 (mouse): S178

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (1, 2), mutation of modification site (1), phosphoamino acid analysis (1, 2), phosphopeptide mapping (1, 2)
Relevant cell line - cell type - tissue:	COS (fibroblast) (1, 2)

Controlled by

Putative upstream kinases:	CDK1 (mouse) (1)
Kinases, in vitro:	CDK1 (mouse) (1, 2)

Downstream Regulation

Effects of modification on CREM iso3:	inhibition (1)
Effects of modification on biological processes:	transcription, altered (1)

	References

1	de Groot RP, Derua R, Goris J, Sassone-Corsi P (1993) Phosphorylation and negative regulation of the transcriptional activator CREM by p34cdc2. Mol Endocrinol 7, 1495-50 8114763 Curated Info
2	de Groot RP, et al. (1993) Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12, 3903-11 8404858 Curated Info

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