Tyr900

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Phosphorylation Site Page:

Site Information

EHAPAEMyDIMKTCW SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: Kit (mouse): Y902

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (1), mutation of modification site (1), phospho-antibody (1), phosphoamino acid analysis (1)
Relevant cell line - cell type - tissue:	3T3 (fibroblast) (1), PAE (endothelial) (1)

Controlled by

Kinases, in vitro:	Src (mouse) (1)
Treatments:	SU6656 (1)

Downstream Regulation

Effects of modification on Kit:	molecular association, regulation (1), protein stabilization (1)
Induce interaction with:	Crk (human) (1), PIK3C2A (human) (1)

	References

1	Lennartsson J, et al. (2003) Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. Exp Cell Res 288, 110-8 12878163 Curated Info

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