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Phosphorylation Site Page:
Tyr900 - Kit (human)

Site Information
EHAPAEMyDIMKTCW    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: Kit (mouse): Y902, Kit (rat): Y901
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450042

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (1), mutation of modification site (1), phospho-antibody (1), phosphoamino acid analysis (1)
Relevant cell line - cell type - tissue: 3T3 (fibroblast) (1), PAE (endothelial) (1)

Controlled by
Kinases, in vitro: Src (mouse) (1)
Treatments: SU6656 (1)

Downstream Regulation
Effects of modification on Kit: molecular association, regulation (1), protein stabilization (1)
Induce interaction with: CRK (human) (1), PIK3C2A (human) (1)



Lennartsson J, et al. (2003) Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. Exp Cell Res 288, 110-8
12878163   Curated Info

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