Ser741

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Phosphorylation Site Page:

Site Information

TKADKRRsVRIGSYI SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: Kit (mouse): S743

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (1), mutation of modification site (1), phosphoamino acid analysis (1)
Relevant cell line - cell type - tissue:	PAE (endothelial) (1)

Controlled by

Kinases, in vitro:	PKCA (human) (1)
Treatments:	SCF (1)

Downstream Regulation

Effects of modification on Kit:

enzymatic activity, inhibited (1), phosphorylation (1)

	References

1	Blume-Jensen P, Wernstedt C, Heldin CH, Rönnstrand L (1995) Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells. J Biol Chem 270, 14192-200 7539802 Curated Info

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