Ser503

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Phosphorylation Site Page:

Site Information

QQSKRPTsASSSPTE SwissProt Entrez-Gene

Predicted information: Scansite

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	[32P] bio-synthetic labeling (3, 4), electrophoretic mobility shift (2), immunoprecipitation (2, 4), mutation of modification site (1, 2, 3, 4), phospho-antibody (2), phosphoamino acid analysis (4), western blotting (3)
Relevant cell line - cell type - tissue:	3T3 (fibroblast) (3), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (2), COS (fibroblast) (4), hepatocyte (1), hepatocyte-liver (2), liver (1)

Controlled by

Putative upstream kinases:	PKCA (rat) (4)
Treatments:	insulin (3), phorbol ester (4), staurosporine (4)

Downstream Regulation

Effects of modification on CEACAM1:

activation (1, 3, 4), intracellular localization (2), receptor internalization, altered (1)

	References

1	Poy MN, et al. (2002) CEACAM1 regulates insulin clearance in liver. Nat Genet 30, 270-6 11850617 Curated Info
2	Choice CV, Poy MN, Formisano P, Najjar SM (1999) Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase. J Cell Biochem 76, 133-42 10581007 Curated Info
3	Najjar SM, et al. (1995) Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 34, 9341-9 7626603 Curated Info
4	Sippel CJ, Fallon RJ, Perlmutter DH (1994) Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation. J Biol Chem 269, 19539-45 7518458 Curated Info

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