Ser503
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Phosphorylation Site Page:
Ser503 - CEACAM1 (rat)

Site Information
QQSKRPTsASSSPTE    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CEACAM1 (human): S508, CEACAM1 (mouse): S503, CEACAM1 iso9 (human): , CEACAM1 iso8 (human):
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448536

In vivo Characterization
Methods used to characterize site in vivo: [32P] bio-synthetic labeling (3, 4), electrophoretic mobility shift (2), immunoprecipitation (2, 4), mutation of modification site (1, 2, 3, 4), phospho-antibody (2), phosphoamino acid analysis (4), western blotting (3)
Relevant cell line - cell type - tissue: 3T3 (fibroblast) (3), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] (2), COS (fibroblast) (4), hepatocyte (1), hepatocyte-liver (2), liver (1)

Controlled by
Putative upstream kinases: PKCA (rat) (4)
Treatments: insulin (3), phorbol ester (4), staurosporine (4)

Downstream Regulation
Effects of modification on CEACAM1: activity, induced (1, 3, 4), intracellular localization (2), receptor internalization, altered (1)


References

1

Poy MN, et al. (2002) CEACAM1 regulates insulin clearance in liver. Nat Genet 30, 270-6
11850617   Curated Info

2

Choice CV, Poy MN, Formisano P, Najjar SM (1999) Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase. J Cell Biochem 76, 133-42
10581007   Curated Info

3

Najjar SM, et al. (1995) Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 34, 9341-9
7626603   Curated Info

4

Sippel CJ, Fallon RJ, Perlmutter DH (1994) Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation. J Biol Chem 269, 19539-45
7518458   Curated Info

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