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In vivo Characterization |
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| Methods used to characterize site in vivo: |
[32P] bio-synthetic labeling (17), mass spectrometry (6, 7, 8, 9, 10, 11), phospho-antibody (5, 12, 13, 14, 15), phosphopeptide mapping (17), western blotting (5, 12, 13, 14, 15)
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| Disease tissue studied: |
liver cancer (17)
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| Relevant cell line - cell type - tissue: |
adipocyte-adipose tissue (14), brain (6, 7, 10), Fao (hepatic) (17), liver (5, 12, 13), PC-12 (chromaffin) (8, 9, 11), vascular smooth muscle cell ('muscle, smooth') (15)
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1
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Jun HJ, et al. (2012) The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation. Cancer Res 72, 3764-74
22659450
Curated Info
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2
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(2009) CST Curation Set: 8467; Year: 2009; Biosample: ST-31-BL; Disease: ischemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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3
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(2009) CST Curation Set: 8461; Year: 2009; Biosample: ST-23-BL; Disease: ischemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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4
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(2009) CST Curation Set: 8435; Year: 2009; Biosample: ST-6-BL; Disease: ischemia; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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5
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Muñoz MC, et al. (2009) TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. J Endocrinol 201, 185-97
19251743
Curated Info
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6
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(2009) CST Curation Set: 5862; Year: 2009; Biosample: brain; Disease: -; Treatment: sham; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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7
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(2009) CST Curation Set: 5864; Year: 2009; Biosample: brain; Disease: -; Treatment: seizure; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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8
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(2008) CST Curation Set: 5264; Year: 2008; Biosample: PC-12; Disease: pheochromocytoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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9
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(2008) CST Curation Set: 5266; Year: 2008; Biosample: PC-12; Disease: pheochromocytoma; Treatment: PACAP; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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10
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(2008) CST Curation Set: 5222; Year: 2008; Biosample: brain; Disease: -; Treatment: ischemia; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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11
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(2008) CST Curation Set: 4012; Year: 2008; Biosample: PC-12; Disease: pheochromocytoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info
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12
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Ma Y, et al. (2004) Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. Endocrinology 145, 5168-76
15297437
Curated Info
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13
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Schliess F, et al. (2004) Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J Biol Chem 279, 21294-301
14985360
Curated Info
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14
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Hers I, et al. (2002) Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Biochem J 368, 875-84
12220227
Curated Info
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15
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Motley ED, et al. (2002) Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. Hypertension 39, 508-12
11882599
Curated Info
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16
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Kruszynska YT, Halban PA, Kahn CR, White MF (1990) Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats. Diabetologia 33, 77-83
2158467
Curated Info
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17
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White MF, Shoelson SE, Keutmann H, Kahn CR (1988) A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem 263, 2969-80
2449432
Curated Info
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