Ser34
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Phosphorylation Site Page:
Ser34 - RhoGDI alpha (rat)

Site Information
YKPPAQKsIQEIQEL    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: RhoGDI alpha (mouse): S34, RhoGDI alpha (human): S34, RhoGDI alpha iso3 (human): S34
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: mutation of modification site (2), phospho-antibody (1, 2), western blotting (1, 2)
Disease tissue studied: adrenal cancer (2), pheochromocytoma (2)
Relevant cell line - cell type - tissue: fibroblast-embryo (1), PC-12 (chromaffin) (2)

Controlled by
Putative upstream kinases: PAK2 (human) (2)
Kinases, in vitro: PAK2 (human) (2)
Treatments: U73122 (1)

Downstream Regulation
Effects of modification on RhoGDI alpha: molecular association, regulation (2)
Effects of modification on biological processes: cell growth, altered (2)
Inhibit interaction with: Cdc42 iso1 (human) (2), RAC1 (rat) (2)


References

1

Dovas A, et al. (2010) Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. J Biol Chem 285, 23296-308
20472934   Curated Info

2

Shin EY, et al. (2009) Phosphorylation of RhoGDI1 by p21-activated kinase 2 mediates basic fibroblast growth factor-stimulated neurite outgrowth in PC12 cells. Biochem Biophys Res Commun 379, 384-9
19103160   Curated Info

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