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Phosphorylation Site Page:
Ser34 - RhoGDI alpha (rat)

Site Information
YKPPAQKsIQEIQEL    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: RhoGDI alpha (mouse): S34, RhoGDI alpha (human): S34, RHOGDI alpha iso3 (human): S34
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467490

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1), mutation of modification site (3), phospho-antibody (2, 3), western blotting (2, 3)
Disease tissue studied: adrenal cancer (3), pheochromocytoma (3)
Relevant cell line - cell type - tissue: 'brain, brainstem' (1), 'brain, cerebellum' (1), 'brain, cerebral cortex' (1), adipose tissue (1), fibroblast-embryo (2), intestine (1), kidney (1), liver (1), lung (1), muscle (1), pancreas (1), PC-12 (chromaffin) (3), spleen (1), stomach (1), testis (1), thymus (1)

Controlled by
Putative upstream kinases: PAK2 (human) (3)
Kinases, in vitro: PAK2 (human) (3)
Treatments: U73122 (2)

Downstream Regulation
Effects of modification on RhoGDI alpha: molecular association, regulation (3)
Effects of modification on biological processes: cell growth, altered (3)
Inhibit interaction with: CDC42 iso1 (human) (3), RAC1 (rat) (3)



Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info


Dovas A, et al. (2010) Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. J Biol Chem 285, 23296-308
20472934   Curated Info


Shin EY, et al. (2009) Phosphorylation of RhoGDI1 by p21-activated kinase 2 mediates basic fibroblast growth factor-stimulated neurite outgrowth in PC12 cells. Biochem Biophys Res Commun 379, 384-9
19103160   Curated Info

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