Thr492
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Phosphorylation Site Page:
Thr492 - Tau (rat)

Site Information
KTTPSPKtPPGSGEP    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: Tau (mouse): T473, Tau iso8 (human): T181, Tau iso3 (human): T87, Tau iso2 (human): T123, Tau iso6 (human): T123, Tau iso5 (human): T181, Tau (cow): T172, Tau (human): T498, Tau iso3 (mouse): T170, Tau iso7 (mouse): T112, Tau iso7 (human): T152
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: amino acid analysis (4), mass spectrometry (2), peptide sequencing (4), phospho-antibody (3), phosphoamino acid analysis (4)
Disease tissue studied: Alzheimer's disease (3)
Relevant cell line - cell type - tissue: 'brain, forebrain' (2), 'neuron, cerebellar granule'-brain (3), brain (4)

Controlled by
Treatments: anoxia (3)



References

1

Nie J, Duan L, Yan Z, Niu Q (2013) Tau hyperphosphorylation is associated with spatial learning and memory after exposure to benzo[a]pyrene in SD rats. Neurotox Res 24, 461-71
23508864   Curated Info

2

Edbauer D, et al. (2009) Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics 8, 681-95
19054758   Curated Info

3

Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info

4

Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info

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