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Phosphorylation Site Page:
Thr492 - Tau (rat)

Site Information
KTTPSPKtPPGSGEP    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: Tau (mouse): T473, Tau iso8 (human): T181, Tau iso3 (human): T87, Tau iso2 (human): T123, Tau iso6 (human): T123, Tau iso5 (human): T181, Tau (cow): T172, Tau (human): T498, Tau iso3 (mouse): T170, Tau iso7 (mouse): T112, Tau iso7 (human): T152
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447932

In vivo Characterization
Methods used to characterize site in vivo: amino acid analysis (6), mass spectrometry (2, 3, 4), peptide sequencing (6), phospho-antibody (5), phosphoamino acid analysis (6)
Disease tissue studied: Alzheimer's disease (5)
Relevant cell line - cell type - tissue: 'brain, brainstem' (3), 'brain, cerebellum' (3), 'brain, cerebral cortex' (3), 'brain, forebrain' (4), 'neuron, cerebellar granule'-brain (5), brain (6), PC-12 (chromaffin) (2), PC-12 (chromaffin) [TrkA (rat), transfection] (2)

Controlled by
Treatments: anoxia (5)



Nie J, Duan L, Yan Z, Niu Q (2013) Tau hyperphosphorylation is associated with spatial learning and memory after exposure to benzo[a]pyrene in SD rats. Neurotox Res 24, 461-71
23508864   Curated Info


Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30
22027198   Curated Info


Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info


Edbauer D, et al. (2009) Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics 8, 681-95
19054758   Curated Info


Liu R, et al. (2005) Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem 94, 1225-34
15992372   Curated Info


Watanabe A, et al. (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268, 25712-7
8245007   Curated Info

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