Tyr921

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Phosphorylation Site Page:

Tyr921 - ITGB4 (human)

Site Information

LKVAPGYyTLTADQD SwissProt Entrez-Gene

Predicted information: Scansite

Orthologous residues: ITGB4 iso2 (human): Y921, ITGB4 iso3 (mouse): Y923, ITGB4 (mouse): Y923, ITGB4 iso3 (human): Y921, ITGB4 iso2 (mouse): Y923, ITGB4 (rat): Y923

Blast this site against: NCBI SwissProt PDB

In vivo Characterization

Methods used to characterize site in vivo:	mass spectrometry (1, 2, 3, 5, 6, 7, 8)
Disease tissue studied:	gastric cancer (1, 5, 7, 8), gastric carcinoma (1, 5, 7), leukemia (3), chronic myelogenous leukemia (3), liver cancer (2, 6), cholangiocellular carcinoma (2), hepatocellular carcinoma (6)
Relevant cell line - cell type - tissue:	hepatocyte-liver (6), K562 (erythroid) (3), KATO III (gastric) (8), liver (2), MKN-45 (gastric) (1, 5, 7)

	References

1	(2011) CST Curation Set: 11914; Year: 2011; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	Gu TL, et al. (2011) Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One 6, e15640 21253578 Curated Info
3	(2010) CST Curation Set: 9956; Year: 2010; Biosample: K562; Disease: chronic myelogenous leukemia; Treatment: normal; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	(2010) CST Curation Set: 9475; Year: 2010; Biosample: RJ-286024T; Disease: liver cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
5	(2010) CST Curation Set: 9061; Year: 2010; Biosample: MKN-45; Disease: gastric carcinoma; Treatment: DMSO; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
6	(2009) CST Curation Set: 7538; Year: 2009; Biosample: hepatocyte(liver); Disease: liver cancer; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	Guo A, et al. (2008) Signaling networks assembled by oncogenic EGFR and c-Met. Proc Natl Acad Sci U S A 105, 692-7 18180459 Curated Info
8	(2006) CST Curation Set: 1645; Year: 2006; Biosample: KATO III; Disease: gastric carcinoma; Treatment: untreated; Specificity of Antibody Used to Purify Peptides prior to MS2: anti-pTyr Antibody Used to Purify Peptides prior to MS2: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info

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