Ser552
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Phosphorylation Site Page:
Ser552 - CTNNB1 (mouse)

Site Information
QDTQRRTsMGGTQQQ    SwissProt Entrez-Gene
Predicted information: Scansite
Orthologous residues: CTNNB1 (human): S552, CTNNB1 (rat): S552
Blast this site against: NCBI  SwissProt  PDB 

In vivo Characterization
Methods used to characterize site in vivo: immunoprecipitation (13), mass spectrometry (1, 2, 3, 4, 5, 7, 10, 11, 12, 14), microscopy-colocalization with upstream kinase (6), phospho-antibody (6, 8, 9, 13), western blotting (8, 9)
Disease tissue studied: anthrax (4), melanoma skin cancer (12), Cowden disease (13)
Relevant cell line - cell type - tissue: 'brain, cerebral cortex' (11), 'brain, cortex' (9), 'fat, brown'-'fat, brown' (5), brain (1, 5, 7), epithelial (8), epithelial [PIK3R1 (mouse), homozygous knockout] (6), heart (5), intestine (13), kidney (5), liver (5, 14), lung (5), MEF (fibroblast) (3), MEF (fibroblast) [p53 (mouse), homozygous knockout] (2), MEF (fibroblast) [TSC2 (mouse), homozygous knockout] (3), mpkCCD (renal) (10), pancreas (5), skin [mGluR1 (mouse), transgenic, TG mutant mice] (12), spleen (4, 5), testis (5)

Controlled by
Regulatory protein: IFNG (mouse) (8), PIK3R1 (mouse) (6), PTEN (mouse) (13)
Putative upstream kinases: Akt1 (mouse) (9)
Kinases, in vitro: Akt1 (human) (13)
Treatments: anti-CD3 (6), IL-22 (8), IL-6 (8), inflammation (8), LY294002 (6), piroxicam (6), tricibine (8, 9)

Downstream Regulation
Effects of modification on CTNNB1: intracellular localization (13)
Effects of modification on biological processes: transcription, altered (9)

Disease / Diagnostics Relevance
Relevant diseases: Cowden disease (13)

References

1

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

2

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

3

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

4

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

6

Lee G, et al. (2010) Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139, 869-81, 881.e1-9
20580720   Curated Info

7

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

8

Nava P, et al. (2010) Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32, 392-402
20303298   Curated Info

9

Zhang J, et al. (2010) Cortical neural precursors inhibit their own differentiation via N-cadherin maintenance of beta-catenin signaling. Dev Cell 18, 472-9
20230753   Curated Info

10

Rinschen MM, et al. (2010) Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells. Proc Natl Acad Sci U S A 107, 3882-7
20139300   Curated Info

11

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

12

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

13

He XC, et al. (2007) PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 39, 189-98
17237784   Curated Info

14

Villén J, Beausoleil SA, Gerber SA, Gygi SP (2007) Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104, 1488-93
17242355   Curated Info

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